Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors

Yuen Gao et al. characterize deficits in brain morphology, behavior, and gene expression following genetic ablation of the histone methyltransferase, ASH1L, during brain development in mice. Their results provide new insight into links between ASH1L activity and neurodevelopmental disorders.

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Autores principales:	Yuen Gao, Natalia Duque-Wilckens, Mohammad B. Aljazi, Yan Wu, Adam J. Moeser, George I. Mias, Alfred J. Robison, Jin He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4b96d495f04d482b9a52d8c90fd24875
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spelling	oai:doaj.org-article:4b96d495f04d482b9a52d8c90fd248752021-12-02T17:23:26ZLoss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors10.1038/s42003-021-02282-z2399-3642https://doaj.org/article/4b96d495f04d482b9a52d8c90fd248752021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02282-zhttps://doaj.org/toc/2399-3642Yuen Gao et al. characterize deficits in brain morphology, behavior, and gene expression following genetic ablation of the histone methyltransferase, ASH1L, during brain development in mice. Their results provide new insight into links between ASH1L activity and neurodevelopmental disorders.Yuen GaoNatalia Duque-WilckensMohammad B. AljaziYan WuAdam J. MoeserGeorge I. MiasAlfred J. RobisonJin HeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yuen Gao Natalia Duque-Wilckens Mohammad B. Aljazi Yan Wu Adam J. Moeser George I. Mias Alfred J. Robison Jin He Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
description	Yuen Gao et al. characterize deficits in brain morphology, behavior, and gene expression following genetic ablation of the histone methyltransferase, ASH1L, during brain development in mice. Their results provide new insight into links between ASH1L activity and neurodevelopmental disorders.
format	article
author	Yuen Gao Natalia Duque-Wilckens Mohammad B. Aljazi Yan Wu Adam J. Moeser George I. Mias Alfred J. Robison Jin He
author_facet	Yuen Gao Natalia Duque-Wilckens Mohammad B. Aljazi Yan Wu Adam J. Moeser George I. Mias Alfred J. Robison Jin He
author_sort	Yuen Gao
title	Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
title_short	Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
title_full	Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
title_fullStr	Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
title_full_unstemmed	Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
title_sort	loss of histone methyltransferase ash1l in the developing mouse brain causes autistic-like behaviors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b96d495f04d482b9a52d8c90fd24875
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Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors

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