Ensa controls S-phase length by modulating Treslin levels
The Greatwall/Ensa/PP2A-B55 pathway controls mitotic substrate phosphorylation and mitotic entry. Here the authors show that cells regulate S phase duration by controlling the ubiquitin-proteasome degradation of Treslin in a Gwl/Ensa-dependent pathway.
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Nature Portfolio
2017
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oai:doaj.org-article:4b97b11010a7439ab7bbf5e1c7ec312e2021-12-02T14:16:47ZEnsa controls S-phase length by modulating Treslin levels10.1038/s41467-017-00339-42041-1723https://doaj.org/article/4b97b11010a7439ab7bbf5e1c7ec312e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00339-4https://doaj.org/toc/2041-1723The Greatwall/Ensa/PP2A-B55 pathway controls mitotic substrate phosphorylation and mitotic entry. Here the authors show that cells regulate S phase duration by controlling the ubiquitin-proteasome degradation of Treslin in a Gwl/Ensa-dependent pathway.Sophie CharrasseAicha Gharbi-AyachiAndrew BurgessJorge VeraKhaled HachedPeggy RaynaudEtienne SchwobThierry LorcaAnna CastroNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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Science Q Sophie Charrasse Aicha Gharbi-Ayachi Andrew Burgess Jorge Vera Khaled Hached Peggy Raynaud Etienne Schwob Thierry Lorca Anna Castro Ensa controls S-phase length by modulating Treslin levels |
description |
The Greatwall/Ensa/PP2A-B55 pathway controls mitotic substrate phosphorylation and mitotic entry. Here the authors show that cells regulate S phase duration by controlling the ubiquitin-proteasome degradation of Treslin in a Gwl/Ensa-dependent pathway. |
format |
article |
author |
Sophie Charrasse Aicha Gharbi-Ayachi Andrew Burgess Jorge Vera Khaled Hached Peggy Raynaud Etienne Schwob Thierry Lorca Anna Castro |
author_facet |
Sophie Charrasse Aicha Gharbi-Ayachi Andrew Burgess Jorge Vera Khaled Hached Peggy Raynaud Etienne Schwob Thierry Lorca Anna Castro |
author_sort |
Sophie Charrasse |
title |
Ensa controls S-phase length by modulating Treslin levels |
title_short |
Ensa controls S-phase length by modulating Treslin levels |
title_full |
Ensa controls S-phase length by modulating Treslin levels |
title_fullStr |
Ensa controls S-phase length by modulating Treslin levels |
title_full_unstemmed |
Ensa controls S-phase length by modulating Treslin levels |
title_sort |
ensa controls s-phase length by modulating treslin levels |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/4b97b11010a7439ab7bbf5e1c7ec312e |
work_keys_str_mv |
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1718391665497997312 |