Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis
Purpose: Using meta-analysis to evaluate the effect of various long-term exercises (more than 4 weeks) on liver lipid metabolism of Chinese patients with non-alcoholic fatty liver disease (NAFLD) and provides more targeted exercise recommendations.Methods: Four databases consisting of PubMed, Web of...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:4b98bdab2c1f4154889b309379fcc8622021-11-22T07:19:57ZEffect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis1664-042X10.3389/fphys.2021.748517https://doaj.org/article/4b98bdab2c1f4154889b309379fcc8622021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.748517/fullhttps://doaj.org/toc/1664-042XPurpose: Using meta-analysis to evaluate the effect of various long-term exercises (more than 4 weeks) on liver lipid metabolism of Chinese patients with non-alcoholic fatty liver disease (NAFLD) and provides more targeted exercise recommendations.Methods: Four databases consisting of PubMed, Web of Science, China Science and Technology Journal Database (VIP), China Knowledge Resource Integrated Database (CNKI) were searched up to May 2021. Randomized controlled trials (RCTs) were eligible, and the outcomes of body composition, lipid metabolism [including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C)], and liver function [including alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] were used to assess the effectiveness of long-term exercise on Chinese patients with NAFLD.Results: Eleven articles with a total of 13 data points (involving 1,006 participants) satisfied the inclusion criteria and were pooled in the meta-analysis. The findings demonstrated that long-term exercise decreased the level of TG [−0.50, 95%CI (−0.64, −0.36)], TC [−0.55, 95%CI (−0.92, −0.18)], LDL-C [−0.29, 95%CI (−0.43, −0.15)], ALT [−3.45, 95%CI (−6.78, −0.12)], AST [−6.91, 95%CI (−10.00, −3.81)], and body mass index (BMI) of patients who did exercise last more than 6 months [−1.55, 95%CI (−2.32, −0.79)] significantly. The effect on HDL-C was not obvious.Conclusion: Long-term exercise can improve the levels of TG, TC, LDL-C, ALT, and AST in Chinese patients with NAFLD significantly, and exercise last more than 6 months can decrease the BMI of Chinese patients with NAFLD.Ye GaoYe GaoJiandong LuJiandong LuXinhong LiuXinhong LiuJingqi LiuJingqi LiuQirui MaQirui MaYajun ShiYajun ShiHao SuFrontiers Media S.A.articlelong-term exercisenon-alcoholic fatty liver diseaselipid metabolismmeta-analysissystematic reviewPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
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DOAJ |
| language |
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| topic |
long-term exercise non-alcoholic fatty liver disease lipid metabolism meta-analysis systematic review Physiology QP1-981 |
| spellingShingle |
long-term exercise non-alcoholic fatty liver disease lipid metabolism meta-analysis systematic review Physiology QP1-981 Ye Gao Ye Gao Jiandong Lu Jiandong Lu Xinhong Liu Xinhong Liu Jingqi Liu Jingqi Liu Qirui Ma Qirui Ma Yajun Shi Yajun Shi Hao Su Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis |
| description |
Purpose: Using meta-analysis to evaluate the effect of various long-term exercises (more than 4 weeks) on liver lipid metabolism of Chinese patients with non-alcoholic fatty liver disease (NAFLD) and provides more targeted exercise recommendations.Methods: Four databases consisting of PubMed, Web of Science, China Science and Technology Journal Database (VIP), China Knowledge Resource Integrated Database (CNKI) were searched up to May 2021. Randomized controlled trials (RCTs) were eligible, and the outcomes of body composition, lipid metabolism [including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C)], and liver function [including alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] were used to assess the effectiveness of long-term exercise on Chinese patients with NAFLD.Results: Eleven articles with a total of 13 data points (involving 1,006 participants) satisfied the inclusion criteria and were pooled in the meta-analysis. The findings demonstrated that long-term exercise decreased the level of TG [−0.50, 95%CI (−0.64, −0.36)], TC [−0.55, 95%CI (−0.92, −0.18)], LDL-C [−0.29, 95%CI (−0.43, −0.15)], ALT [−3.45, 95%CI (−6.78, −0.12)], AST [−6.91, 95%CI (−10.00, −3.81)], and body mass index (BMI) of patients who did exercise last more than 6 months [−1.55, 95%CI (−2.32, −0.79)] significantly. The effect on HDL-C was not obvious.Conclusion: Long-term exercise can improve the levels of TG, TC, LDL-C, ALT, and AST in Chinese patients with NAFLD significantly, and exercise last more than 6 months can decrease the BMI of Chinese patients with NAFLD. |
| format |
article |
| author |
Ye Gao Ye Gao Jiandong Lu Jiandong Lu Xinhong Liu Xinhong Liu Jingqi Liu Jingqi Liu Qirui Ma Qirui Ma Yajun Shi Yajun Shi Hao Su |
| author_facet |
Ye Gao Ye Gao Jiandong Lu Jiandong Lu Xinhong Liu Xinhong Liu Jingqi Liu Jingqi Liu Qirui Ma Qirui Ma Yajun Shi Yajun Shi Hao Su |
| author_sort |
Ye Gao |
| title |
Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis |
| title_short |
Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis |
| title_full |
Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis |
| title_fullStr |
Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis |
| title_full_unstemmed |
Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis |
| title_sort |
effect of long-term exercise on liver lipid metabolism in chinese patients with nafld: a systematic review and meta-analysis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/4b98bdab2c1f4154889b309379fcc862 |
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