Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream

Nanoparticle-based technologies are rapidly expanding into many areas of biomedicine and molecular science. The unique ability of magnetic nanoparticles to respond to the magnetic field makes them especially attractive for a number of in vivo applications including magnetofection. The magnetofection...

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Autores principales:	Artem A. Sizikov, Petr I. Nikitin, Maxim P. Nikitin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnetofection in vivo magnetic nanoparticles iron oxide gene delivery gene vectors Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4b9bee9ccc7c4ea1bf27b39f0e2f5099
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id	oai:doaj.org-article:4b9bee9ccc7c4ea1bf27b39f0e2f5099
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spelling	oai:doaj.org-article:4b9bee9ccc7c4ea1bf27b39f0e2f50992021-11-25T18:41:57ZMagnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream10.3390/pharmaceutics131119271999-4923https://doaj.org/article/4b9bee9ccc7c4ea1bf27b39f0e2f50992021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1927https://doaj.org/toc/1999-4923Nanoparticle-based technologies are rapidly expanding into many areas of biomedicine and molecular science. The unique ability of magnetic nanoparticles to respond to the magnetic field makes them especially attractive for a number of in vivo applications including magnetofection. The magnetofection principle consists of the accumulation and retention of magnetic nanoparticles carrying nucleic acids in the area of magnetic field application. The method is highly promising as a clinically efficient tool for gene delivery in vivo. However, the data on in vivo magnetofection are often only descriptive or poorly studied, insufficiently systematized, and sometimes even contradictory. Therefore, the aim of the review was to systematize and analyze the data that influence the in vivo magnetofection processes after the systemic injection of magnetic nanostructures. The main emphasis is placed on the structure and coating of the nanomagnetic vectors. The present problems and future trends of the method development are also considered.Artem A. SizikovPetr I. NikitinMaxim P. NikitinMDPI AGarticlemagnetofection in vivomagnetic nanoparticlesiron oxidegene deliverygene vectorsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1927, p 1927 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetofection in vivo magnetic nanoparticles iron oxide gene delivery gene vectors Pharmacy and materia medica RS1-441
spellingShingle	magnetofection in vivo magnetic nanoparticles iron oxide gene delivery gene vectors Pharmacy and materia medica RS1-441 Artem A. Sizikov Petr I. Nikitin Maxim P. Nikitin Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream
description	Nanoparticle-based technologies are rapidly expanding into many areas of biomedicine and molecular science. The unique ability of magnetic nanoparticles to respond to the magnetic field makes them especially attractive for a number of in vivo applications including magnetofection. The magnetofection principle consists of the accumulation and retention of magnetic nanoparticles carrying nucleic acids in the area of magnetic field application. The method is highly promising as a clinically efficient tool for gene delivery in vivo. However, the data on in vivo magnetofection are often only descriptive or poorly studied, insufficiently systematized, and sometimes even contradictory. Therefore, the aim of the review was to systematize and analyze the data that influence the in vivo magnetofection processes after the systemic injection of magnetic nanostructures. The main emphasis is placed on the structure and coating of the nanomagnetic vectors. The present problems and future trends of the method development are also considered.
format	article
author	Artem A. Sizikov Petr I. Nikitin Maxim P. Nikitin
author_facet	Artem A. Sizikov Petr I. Nikitin Maxim P. Nikitin
author_sort	Artem A. Sizikov
title	Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream
title_short	Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream
title_full	Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream
title_fullStr	Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream
title_full_unstemmed	Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream
title_sort	magnetofection in vivo by nanomagnetic carriers systemically administered into the bloodstream
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4b9bee9ccc7c4ea1bf27b39f0e2f5099
work_keys_str_mv	AT artemasizikov magnetofectioninvivobynanomagneticcarrierssystemicallyadministeredintothebloodstream AT petrinikitin magnetofectioninvivobynanomagneticcarrierssystemicallyadministeredintothebloodstream AT maximpnikitin magnetofectioninvivobynanomagneticcarrierssystemicallyadministeredintothebloodstream
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Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream

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