An alternative model for (breast) cancer predisposition

Abstract While environmental factors can greatly increase cancer risk, it is clear that an individual’s genetic constitution has strong impact on tumor formation. Hereby we present an alternative cancer predisposition model built on the assumption that efficiencies of DNA maintenance mechanisms in n...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Erik Teugels, Sylvia De Brakeleer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4b9f495cbca340e2a7afda3b6b1a8835
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4b9f495cbca340e2a7afda3b6b1a8835
record_format	dspace
spelling	oai:doaj.org-article:4b9f495cbca340e2a7afda3b6b1a88352021-12-02T11:50:52ZAn alternative model for (breast) cancer predisposition10.1038/s41523-017-0017-72374-4677https://doaj.org/article/4b9f495cbca340e2a7afda3b6b1a88352017-04-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0017-7https://doaj.org/toc/2374-4677Abstract While environmental factors can greatly increase cancer risk, it is clear that an individual’s genetic constitution has strong impact on tumor formation. Hereby we present an alternative cancer predisposition model built on the assumption that efficiencies of DNA maintenance mechanisms in normal cells are similar but not identical for each person. Small variations in an individual’s genetic constitution may result in slightly increased genomic instability and generate typical mutational signatures in normal cells. With recent and expected advances in the next-generation sequencing field, qualitative and quantitative establishment of such mutational signatures in normal tissue must become feasible, and may meanwhile provide a more accurate estimation of individual cancer risks, even in persons without familial antecedents. An additional advantage of this approach is that cancer risk assessment will not strictly rely on the individual’s genetic identity, but will also consider other factors (e.g., environmental and age) that can affect genomic integrity.Erik TeugelsSylvia De BrakeleerNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Erik Teugels Sylvia De Brakeleer An alternative model for (breast) cancer predisposition
description	Abstract While environmental factors can greatly increase cancer risk, it is clear that an individual’s genetic constitution has strong impact on tumor formation. Hereby we present an alternative cancer predisposition model built on the assumption that efficiencies of DNA maintenance mechanisms in normal cells are similar but not identical for each person. Small variations in an individual’s genetic constitution may result in slightly increased genomic instability and generate typical mutational signatures in normal cells. With recent and expected advances in the next-generation sequencing field, qualitative and quantitative establishment of such mutational signatures in normal tissue must become feasible, and may meanwhile provide a more accurate estimation of individual cancer risks, even in persons without familial antecedents. An additional advantage of this approach is that cancer risk assessment will not strictly rely on the individual’s genetic identity, but will also consider other factors (e.g., environmental and age) that can affect genomic integrity.
format	article
author	Erik Teugels Sylvia De Brakeleer
author_facet	Erik Teugels Sylvia De Brakeleer
author_sort	Erik Teugels
title	An alternative model for (breast) cancer predisposition
title_short	An alternative model for (breast) cancer predisposition
title_full	An alternative model for (breast) cancer predisposition
title_fullStr	An alternative model for (breast) cancer predisposition
title_full_unstemmed	An alternative model for (breast) cancer predisposition
title_sort	alternative model for (breast) cancer predisposition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4b9f495cbca340e2a7afda3b6b1a8835
work_keys_str_mv	AT erikteugels analternativemodelforbreastcancerpredisposition AT sylviadebrakeleer analternativemodelforbreastcancerpredisposition AT erikteugels alternativemodelforbreastcancerpredisposition AT sylviadebrakeleer alternativemodelforbreastcancerpredisposition
_version_	1718395161171460096

An alternative model for (breast) cancer predisposition

Ejemplares similares