Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that inhibition of metalloprotease 13 may reduce smoot...

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Autores principales:	Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ba0b6d9e607460d92755869c0269433
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spelling	oai:doaj.org-article:4ba0b6d9e607460d92755869c02694332021-12-02T15:10:51ZVulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP1310.1038/s41467-020-17901-22041-1723https://doaj.org/article/4ba0b6d9e607460d92755869c02694332020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17901-2https://doaj.org/toc/2041-1723Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that inhibition of metalloprotease 13 may reduce smooth muscle cell loss.Patricia R. PitrezLuís EstroncaLuís Miguel MonteiroGuillem ColellHelena VazãoDeolinda SantinhaKarim HarhouriDaniel ThorntonClaire NavarroAnne-Laure EgesipeTânia CarvalhoRodrigo L. Dos SantosNicolas LévyJames C. SmithJoão Pedro de MagalhãesAlessandro OriAndreia BernardoAnnachiara De Sandre-GiovannoliXavier NissanAnna RosellLino FerreiraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia R. Pitrez Luís Estronca Luís Miguel Monteiro Guillem Colell Helena Vazão Deolinda Santinha Karim Harhouri Daniel Thornton Claire Navarro Anne-Laure Egesipe Tânia Carvalho Rodrigo L. Dos Santos Nicolas Lévy James C. Smith João Pedro de Magalhães Alessandro Ori Andreia Bernardo Annachiara De Sandre-Giovannoli Xavier Nissan Anna Rosell Lino Ferreira Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
description	Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that inhibition of metalloprotease 13 may reduce smooth muscle cell loss.
format	article
author	Patricia R. Pitrez Luís Estronca Luís Miguel Monteiro Guillem Colell Helena Vazão Deolinda Santinha Karim Harhouri Daniel Thornton Claire Navarro Anne-Laure Egesipe Tânia Carvalho Rodrigo L. Dos Santos Nicolas Lévy James C. Smith João Pedro de Magalhães Alessandro Ori Andreia Bernardo Annachiara De Sandre-Giovannoli Xavier Nissan Anna Rosell Lino Ferreira
author_facet	Patricia R. Pitrez Luís Estronca Luís Miguel Monteiro Guillem Colell Helena Vazão Deolinda Santinha Karim Harhouri Daniel Thornton Claire Navarro Anne-Laure Egesipe Tânia Carvalho Rodrigo L. Dos Santos Nicolas Lévy James C. Smith João Pedro de Magalhães Alessandro Ori Andreia Bernardo Annachiara De Sandre-Giovannoli Xavier Nissan Anna Rosell Lino Ferreira
author_sort	Patricia R. Pitrez
title	Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
title_short	Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
title_full	Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
title_fullStr	Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
title_full_unstemmed	Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
title_sort	vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by mmp13
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4ba0b6d9e607460d92755869c0269433
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Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

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