Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.

Parkinson's disease (PD) is a surprisingly heterogeneous disorder with symptoms including resting tremor, bradykinesia and rigidity. PD has been associated with abnormal task related brain activation in sensory and motor regions as well as reward related network. Although corticostriatal skelet...

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Autores principales:	Rongjun Yu, Bo Liu, Lingling Wang, Jun Chen, Xian Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ba19081cef94a9e8bf16e1e2e5febd2
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spelling	oai:doaj.org-article:4ba19081cef94a9e8bf16e1e2e5febd22021-11-18T07:51:56ZEnhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.1932-620310.1371/journal.pone.0059717https://doaj.org/article/4ba19081cef94a9e8bf16e1e2e5febd22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555758/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Parkinson's disease (PD) is a surprisingly heterogeneous disorder with symptoms including resting tremor, bradykinesia and rigidity. PD has been associated with abnormal task related brain activation in sensory and motor regions as well as reward related network. Although corticostriatal skeletomotor circuit dysfunction is implicated in the neurobiology of Parkinson's disease, the functional connectivity within this circuit at the resting state is still unclear for PD. Here we utilized resting state functional magnetic resonance imaging to measure the functional connectivity of striatum and motor cortex in 19 patients with PD and 20 healthy controls. We found that the putamen, but not the caudate, exhibited enhanced connectivity with supplementary motor area (SMA), using either the putamen or the SMA as the "seed region". Enhanced SMA-amygdala functional connectivity was also found in the PD group, compared with normal controls. Our findings highlight the key role of hyper-connected putamen-SMC circuit in the pathophysiology of PD.Rongjun YuBo LiuLingling WangJun ChenXian LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59717 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rongjun Yu Bo Liu Lingling Wang Jun Chen Xian Liu Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.
description	Parkinson's disease (PD) is a surprisingly heterogeneous disorder with symptoms including resting tremor, bradykinesia and rigidity. PD has been associated with abnormal task related brain activation in sensory and motor regions as well as reward related network. Although corticostriatal skeletomotor circuit dysfunction is implicated in the neurobiology of Parkinson's disease, the functional connectivity within this circuit at the resting state is still unclear for PD. Here we utilized resting state functional magnetic resonance imaging to measure the functional connectivity of striatum and motor cortex in 19 patients with PD and 20 healthy controls. We found that the putamen, but not the caudate, exhibited enhanced connectivity with supplementary motor area (SMA), using either the putamen or the SMA as the "seed region". Enhanced SMA-amygdala functional connectivity was also found in the PD group, compared with normal controls. Our findings highlight the key role of hyper-connected putamen-SMC circuit in the pathophysiology of PD.
format	article
author	Rongjun Yu Bo Liu Lingling Wang Jun Chen Xian Liu
author_facet	Rongjun Yu Bo Liu Lingling Wang Jun Chen Xian Liu
author_sort	Rongjun Yu
title	Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.
title_short	Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.
title_full	Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.
title_fullStr	Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.
title_full_unstemmed	Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.
title_sort	enhanced functional connectivity between putamen and supplementary motor area in parkinson's disease patients.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4ba19081cef94a9e8bf16e1e2e5febd2
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Enhanced functional connectivity between putamen and supplementary motor area in Parkinson's disease patients.

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