Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.

Following pathogen infection the hosts' nervous and immune systems react with coordinated responses to the danger. A key question is how the neuronal and immune responses to pathogens are coordinated, are there common signaling pathways used by both responses? Using C. elegans we show that infe...

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Autores principales:	Rachel McMullan, Alexandra Anderson, Stephen Nurrish
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4ba2d571f5984934b0182ebbe0be602f
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spelling	oai:doaj.org-article:4ba2d571f5984934b0182ebbe0be602f2021-11-18T06:04:46ZBehavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.1553-73661553-737410.1371/journal.ppat.1002530https://doaj.org/article/4ba2d571f5984934b0182ebbe0be602f2012-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22359503/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Following pathogen infection the hosts' nervous and immune systems react with coordinated responses to the danger. A key question is how the neuronal and immune responses to pathogens are coordinated, are there common signaling pathways used by both responses? Using C. elegans we show that infection by pathogenic strains of M. nematophilum, but not exposure to avirulent strains, triggers behavioral and immune responses both of which require a conserved Gαq-RhoGEF Trio-Rho signaling pathway. Upon infection signaling by the Gαq pathway within cholinergic motorneurons is necessary and sufficient to increase release of the neurotransmitter acetylcholine and increase locomotion rates and these behavioral changes result in C. elegans leaving lawns of M. nematophilum. In the immune response to infection signaling by the Gαq pathway within rectal epithelial cells is necessary and sufficient to cause changes in cell morphology resulting in tail swelling that limits the infection. These Gαq mediated behavioral and immune responses to infection are separate, act in a cell autonomous fashion and activation of this pathway in the appropriate cells can trigger these responses in the absence of infection. Within the rectal epithelium the Gαq signaling pathway cooperates with a Ras signaling pathway to activate a Raf-ERK-MAPK pathway to trigger the cell morphology changes, whereas in motorneurons Gαq signaling triggers behavioral responses independent of Ras signaling. Thus, a conserved Gαq pathway cooperates with cell specific factors in the nervous and immune systems to produce appropriate responses to pathogen. Thus, our data suggests that ligands for Gq coupled receptors are likely to be part of the signals generated in response to M. nematophilum infection.Rachel McMullanAlexandra AndersonStephen NurrishPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 2, p e1002530 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Rachel McMullan Alexandra Anderson Stephen Nurrish Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
description	Following pathogen infection the hosts' nervous and immune systems react with coordinated responses to the danger. A key question is how the neuronal and immune responses to pathogens are coordinated, are there common signaling pathways used by both responses? Using C. elegans we show that infection by pathogenic strains of M. nematophilum, but not exposure to avirulent strains, triggers behavioral and immune responses both of which require a conserved Gαq-RhoGEF Trio-Rho signaling pathway. Upon infection signaling by the Gαq pathway within cholinergic motorneurons is necessary and sufficient to increase release of the neurotransmitter acetylcholine and increase locomotion rates and these behavioral changes result in C. elegans leaving lawns of M. nematophilum. In the immune response to infection signaling by the Gαq pathway within rectal epithelial cells is necessary and sufficient to cause changes in cell morphology resulting in tail swelling that limits the infection. These Gαq mediated behavioral and immune responses to infection are separate, act in a cell autonomous fashion and activation of this pathway in the appropriate cells can trigger these responses in the absence of infection. Within the rectal epithelium the Gαq signaling pathway cooperates with a Ras signaling pathway to activate a Raf-ERK-MAPK pathway to trigger the cell morphology changes, whereas in motorneurons Gαq signaling triggers behavioral responses independent of Ras signaling. Thus, a conserved Gαq pathway cooperates with cell specific factors in the nervous and immune systems to produce appropriate responses to pathogen. Thus, our data suggests that ligands for Gq coupled receptors are likely to be part of the signals generated in response to M. nematophilum infection.
format	article
author	Rachel McMullan Alexandra Anderson Stephen Nurrish
author_facet	Rachel McMullan Alexandra Anderson Stephen Nurrish
author_sort	Rachel McMullan
title	Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
title_short	Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
title_full	Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
title_fullStr	Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
title_full_unstemmed	Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
title_sort	behavioral and immune responses to infection require gαq- rhoa signaling in c. elegans.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4ba2d571f5984934b0182ebbe0be602f
work_keys_str_mv	AT rachelmcmullan behavioralandimmuneresponsestoinfectionrequiregaqrhoasignalingincelegans AT alexandraanderson behavioralandimmuneresponsestoinfectionrequiregaqrhoasignalingincelegans AT stephennurrish behavioralandimmuneresponsestoinfectionrequiregaqrhoasignalingincelegans
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Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.

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