Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer

Abstract The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented bu...

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Autores principales:	Garazi Retegui, Jaione Etxeberria, María Dolores Ugarte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ba450c4ae43402f8be61ffd44f8b2e5
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id	oai:doaj.org-article:4ba450c4ae43402f8be61ffd44f8b2e5
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spelling	oai:doaj.org-article:4ba450c4ae43402f8be61ffd44f8b2e52021-11-21T12:24:26ZEstimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer10.1038/s41598-021-01765-72045-2322https://doaj.org/article/4ba450c4ae43402f8be61ffd44f8b2e52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01765-7https://doaj.org/toc/2045-2322Abstract The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this requires a clear specification of the target population. This paper provides an in-depth description of LOCP mortality rates by province, age group and gender, giving a complete overview of the disease. This study also presents a methodological challenge. As the number of LOCP cancer cases in small domains (province, age groups and gender) is scarce, univariate spatial models do not provide reliable results or are even impossible to fit. In view of the close link between LOCP and lung cancer, we consider analyzing them jointly by using shared component models. These models allow information-borrowing among diseases, ultimately providing the analysis of cancer sites with few cases at a very disaggregated level. Results show that males have higher mortality rates than females and these rates increase with age. Regions located in the north of Spain show the highest LOCP cancer mortality rates.Garazi ReteguiJaione EtxeberriaMaría Dolores UgarteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Garazi Retegui Jaione Etxeberria María Dolores Ugarte Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
description	Abstract The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this requires a clear specification of the target population. This paper provides an in-depth description of LOCP mortality rates by province, age group and gender, giving a complete overview of the disease. This study also presents a methodological challenge. As the number of LOCP cancer cases in small domains (province, age groups and gender) is scarce, univariate spatial models do not provide reliable results or are even impossible to fit. In view of the close link between LOCP and lung cancer, we consider analyzing them jointly by using shared component models. These models allow information-borrowing among diseases, ultimately providing the analysis of cancer sites with few cases at a very disaggregated level. Results show that males have higher mortality rates than females and these rates increase with age. Regions located in the north of Spain show the highest LOCP cancer mortality rates.
format	article
author	Garazi Retegui Jaione Etxeberria María Dolores Ugarte
author_facet	Garazi Retegui Jaione Etxeberria María Dolores Ugarte
author_sort	Garazi Retegui
title	Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_short	Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_full	Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_fullStr	Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_full_unstemmed	Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_sort	estimating locp cancer mortality rates in small domains in spain using its relationship with lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ba450c4ae43402f8be61ffd44f8b2e5
work_keys_str_mv	AT garaziretegui estimatinglocpcancermortalityratesinsmalldomainsinspainusingitsrelationshipwithlungcancer AT jaioneetxeberria estimatinglocpcancermortalityratesinsmalldomainsinspainusingitsrelationshipwithlungcancer AT mariadoloresugarte estimatinglocpcancermortalityratesinsmalldomainsinspainusingitsrelationshipwithlungcancer
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Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer

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