Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer

Abstract The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented bu...

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Autores principales: Garazi Retegui, Jaione Etxeberria, María Dolores Ugarte
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4ba450c4ae43402f8be61ffd44f8b2e5
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spelling oai:doaj.org-article:4ba450c4ae43402f8be61ffd44f8b2e52021-11-21T12:24:26ZEstimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer10.1038/s41598-021-01765-72045-2322https://doaj.org/article/4ba450c4ae43402f8be61ffd44f8b2e52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01765-7https://doaj.org/toc/2045-2322Abstract The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this requires a clear specification of the target population. This paper provides an in-depth description of LOCP mortality rates by province, age group and gender, giving a complete overview of the disease. This study also presents a methodological challenge. As the number of LOCP cancer cases in small domains (province, age groups and gender) is scarce, univariate spatial models do not provide reliable results or are even impossible to fit. In view of the close link between LOCP and lung cancer, we consider analyzing them jointly by using shared component models. These models allow information-borrowing among diseases, ultimately providing the analysis of cancer sites with few cases at a very disaggregated level. Results show that males have higher mortality rates than females and these rates increase with age. Regions located in the north of Spain show the highest LOCP cancer mortality rates.Garazi ReteguiJaione EtxeberriaMaría Dolores UgarteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Garazi Retegui
Jaione Etxeberria
María Dolores Ugarte
Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
description Abstract The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this requires a clear specification of the target population. This paper provides an in-depth description of LOCP mortality rates by province, age group and gender, giving a complete overview of the disease. This study also presents a methodological challenge. As the number of LOCP cancer cases in small domains (province, age groups and gender) is scarce, univariate spatial models do not provide reliable results or are even impossible to fit. In view of the close link between LOCP and lung cancer, we consider analyzing them jointly by using shared component models. These models allow information-borrowing among diseases, ultimately providing the analysis of cancer sites with few cases at a very disaggregated level. Results show that males have higher mortality rates than females and these rates increase with age. Regions located in the north of Spain show the highest LOCP cancer mortality rates.
format article
author Garazi Retegui
Jaione Etxeberria
María Dolores Ugarte
author_facet Garazi Retegui
Jaione Etxeberria
María Dolores Ugarte
author_sort Garazi Retegui
title Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_short Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_full Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_fullStr Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_full_unstemmed Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_sort estimating locp cancer mortality rates in small domains in spain using its relationship with lung cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4ba450c4ae43402f8be61ffd44f8b2e5
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AT jaioneetxeberria estimatinglocpcancermortalityratesinsmalldomainsinspainusingitsrelationshipwithlungcancer
AT mariadoloresugarte estimatinglocpcancermortalityratesinsmalldomainsinspainusingitsrelationshipwithlungcancer
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