Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Chronic pain in temporomandibular disorder (TMD) is a common health problem. Cumulating evidence indicates that the etiology of TMD pain is complex with multifactorial experience that could hamper the developments of treatments. Preclinical research is a resource to understand the mechanism for TMD...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Keiichiro Okamoto, Mana Hasegawa, Kajita Piriyaprasath, Yoshito Kakihara, Makio Saeki, Kensuke Yamamura
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Temporomandibular disorder pain Stress Brain Trigeminal subnucleus caudalis Deep craniofacial tissue Animal model Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/4ba758031cef468f8604b59b2abd7c51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4ba758031cef468f8604b59b2abd7c51
record_format	dspace
spelling	oai:doaj.org-article:4ba758031cef468f8604b59b2abd7c512021-11-14T04:31:32ZPreclinical models of deep craniofacial nociception and temporomandibular disorder pain1882-761610.1016/j.jdsr.2021.10.002https://doaj.org/article/4ba758031cef468f8604b59b2abd7c512021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1882761621000302https://doaj.org/toc/1882-7616Chronic pain in temporomandibular disorder (TMD) is a common health problem. Cumulating evidence indicates that the etiology of TMD pain is complex with multifactorial experience that could hamper the developments of treatments. Preclinical research is a resource to understand the mechanism for TMD pain, whereas limitations are present as a disease-specific model. It is difficult to incorporate multiple risk factors associated with the etiology that could increase pain responses into a single animal. This article introduces several rodent models which are often employed in the preclinical studies and discusses their validities for TMD pain after the elucidations of the neural mechanisms based on the clinical reports. First, rodent models were classified into two groups with or without inflammation in the deep craniofacial tissues. Next, the characteristics of each model and the procedures to identify deep craniofacial pain were discussed. Emphasis was directed on the findings of the effects of chronic psychological stress, a major risk factor for chronic pain, on the deep craniofacial nociception. Preclinical models have provided clinically relevant information, which could contribute to better understand the basis for TMD pain, while efforts are still required to bridge the gap between animal and human studies.Keiichiro OkamotoMana HasegawaKajita PiriyaprasathYoshito KakiharaMakio SaekiKensuke YamamuraElsevierarticleTemporomandibular disorder painStressBrainTrigeminal subnucleus caudalisDeep craniofacial tissueAnimal modelDentistryRK1-715ENJapanese Dental Science Review, Vol 57, Iss , Pp 231-241 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Temporomandibular disorder pain Stress Brain Trigeminal subnucleus caudalis Deep craniofacial tissue Animal model Dentistry RK1-715
spellingShingle	Temporomandibular disorder pain Stress Brain Trigeminal subnucleus caudalis Deep craniofacial tissue Animal model Dentistry RK1-715 Keiichiro Okamoto Mana Hasegawa Kajita Piriyaprasath Yoshito Kakihara Makio Saeki Kensuke Yamamura Preclinical models of deep craniofacial nociception and temporomandibular disorder pain
description	Chronic pain in temporomandibular disorder (TMD) is a common health problem. Cumulating evidence indicates that the etiology of TMD pain is complex with multifactorial experience that could hamper the developments of treatments. Preclinical research is a resource to understand the mechanism for TMD pain, whereas limitations are present as a disease-specific model. It is difficult to incorporate multiple risk factors associated with the etiology that could increase pain responses into a single animal. This article introduces several rodent models which are often employed in the preclinical studies and discusses their validities for TMD pain after the elucidations of the neural mechanisms based on the clinical reports. First, rodent models were classified into two groups with or without inflammation in the deep craniofacial tissues. Next, the characteristics of each model and the procedures to identify deep craniofacial pain were discussed. Emphasis was directed on the findings of the effects of chronic psychological stress, a major risk factor for chronic pain, on the deep craniofacial nociception. Preclinical models have provided clinically relevant information, which could contribute to better understand the basis for TMD pain, while efforts are still required to bridge the gap between animal and human studies.
format	article
author	Keiichiro Okamoto Mana Hasegawa Kajita Piriyaprasath Yoshito Kakihara Makio Saeki Kensuke Yamamura
author_facet	Keiichiro Okamoto Mana Hasegawa Kajita Piriyaprasath Yoshito Kakihara Makio Saeki Kensuke Yamamura
author_sort	Keiichiro Okamoto
title	Preclinical models of deep craniofacial nociception and temporomandibular disorder pain
title_short	Preclinical models of deep craniofacial nociception and temporomandibular disorder pain
title_full	Preclinical models of deep craniofacial nociception and temporomandibular disorder pain
title_fullStr	Preclinical models of deep craniofacial nociception and temporomandibular disorder pain
title_full_unstemmed	Preclinical models of deep craniofacial nociception and temporomandibular disorder pain
title_sort	preclinical models of deep craniofacial nociception and temporomandibular disorder pain
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4ba758031cef468f8604b59b2abd7c51
work_keys_str_mv	AT keiichirookamoto preclinicalmodelsofdeepcraniofacialnociceptionandtemporomandibulardisorderpain AT manahasegawa preclinicalmodelsofdeepcraniofacialnociceptionandtemporomandibulardisorderpain AT kajitapiriyaprasath preclinicalmodelsofdeepcraniofacialnociceptionandtemporomandibulardisorderpain AT yoshitokakihara preclinicalmodelsofdeepcraniofacialnociceptionandtemporomandibulardisorderpain AT makiosaeki preclinicalmodelsofdeepcraniofacialnociceptionandtemporomandibulardisorderpain AT kensukeyamamura preclinicalmodelsofdeepcraniofacialnociceptionandtemporomandibulardisorderpain
_version_	1718429954501246976

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Ejemplares similares