A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip.
Constitutive STAT signaling provides growth promoting signals in many forms of malignancy. We performed molecular modeling and molecular dynamics studies of the interaction between the regulatory Src homology 2 (SH2) domains of STAT3 and 6 with phosphorylated peptides of the herpesviral oncoprotein...
Guardado en:
Autores principales: | Eman Dey Mazumder, Christophe Jardin, Benjamin Vogel, Elke Heck, Brigitte Scholz, Doris Lengenfelder, Heinrich Sticht, Armin Ensser |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/4ba76dfb69a9424a832b7022242f0b5c |
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