An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases

Roxanne Crosby-Nwaobi, Philip Hykin, Tunde Peto, Sobha Sivaprasad NIHR Clinical Research Facility, NIHR Moorfields Biomedical Research Centre, London, UK Purpose: The aim of this study was to assess the impact of daily oral supplementation with Macushield (10 mg/d meso-zeaxanthin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Crosby-Nwaobi R, Hykin P, Peto T, Sivaprasad S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	acular pigment optical density diabetes central serous retinopathy age related macular degeneration. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4baa0614e2074e48892c207a742fd059
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4baa0614e2074e48892c207a742fd059
record_format	dspace
spelling	oai:doaj.org-article:4baa0614e2074e48892c207a742fd0592021-12-02T06:26:34ZAn exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases1177-5483https://doaj.org/article/4baa0614e2074e48892c207a742fd0592016-05-01T00:00:00Zhttps://www.dovepress.com/an-exploratory-study-evaluating-the-effects-of-macular-carotenoid-supp-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Roxanne Crosby-Nwaobi, Philip Hykin, Tunde Peto, Sobha Sivaprasad NIHR Clinical Research Facility, NIHR Moorfields Biomedical Research Centre, London, UK Purpose: The aim of this study was to assess the impact of daily oral supplementation with Macushield (10 mg/d meso-zeaxanthin, 10 mg/d lutein, and 2 mg/d zeaxanthin) on eye health in patients with retinal diseases by assessing the macular pigment (MP) profile, the visual function, and the quality of life. Methods: Fifty-one patients with various retinal diseases were supplemented daily and followed up for 6 months. The MP optical density was measured using the customized heterochromatic flicker photometry and dual-wavelength autofluorescence. Visual function was evaluated by assessing the change in best corrected visual acuity, contrast sensitivity, and glare sensitivity in mesopic and photopic conditions. Vision-related and general quality of life changes were determined using the National Eye Insititute- Visual Function Questionnaire-25 (NEI-VFQ-25) and EuroQoL-5 dimension questionnaires. Results: A statistically significant increase in the MP optical density was observed using the dual-wavelength autofluorescence (P=0.04) but not with the customized heterochromatic flicker photometry. Statistically significant (P<0.05) improvements in glare sensitivity in low and medium spatial frequencies were observed at 3 months and 6 months. Ceiling effects confounded other visual function tests and quality of life changes. Conclusion: Supplementation with the three carotenoids enhances certain aspects of visual performance in retinal diseases. Keywords: macular pigment optical density, diabetes, central serous retinopathy, age-related macular degenerationCrosby-Nwaobi RHykin PPeto TSivaprasad SDove Medical Pressarticleacular pigment optical densitydiabetescentral serous retinopathyage related macular degeneration.OphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 835-844 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	acular pigment optical density diabetes central serous retinopathy age related macular degeneration. Ophthalmology RE1-994
spellingShingle	acular pigment optical density diabetes central serous retinopathy age related macular degeneration. Ophthalmology RE1-994 Crosby-Nwaobi R Hykin P Peto T Sivaprasad S An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases
description	Roxanne Crosby-Nwaobi, Philip Hykin, Tunde Peto, Sobha Sivaprasad NIHR Clinical Research Facility, NIHR Moorfields Biomedical Research Centre, London, UK Purpose: The aim of this study was to assess the impact of daily oral supplementation with Macushield (10 mg/d meso-zeaxanthin, 10 mg/d lutein, and 2 mg/d zeaxanthin) on eye health in patients with retinal diseases by assessing the macular pigment (MP) profile, the visual function, and the quality of life. Methods: Fifty-one patients with various retinal diseases were supplemented daily and followed up for 6 months. The MP optical density was measured using the customized heterochromatic flicker photometry and dual-wavelength autofluorescence. Visual function was evaluated by assessing the change in best corrected visual acuity, contrast sensitivity, and glare sensitivity in mesopic and photopic conditions. Vision-related and general quality of life changes were determined using the National Eye Insititute- Visual Function Questionnaire-25 (NEI-VFQ-25) and EuroQoL-5 dimension questionnaires. Results: A statistically significant increase in the MP optical density was observed using the dual-wavelength autofluorescence (P=0.04) but not with the customized heterochromatic flicker photometry. Statistically significant (P<0.05) improvements in glare sensitivity in low and medium spatial frequencies were observed at 3 months and 6 months. Ceiling effects confounded other visual function tests and quality of life changes. Conclusion: Supplementation with the three carotenoids enhances certain aspects of visual performance in retinal diseases. Keywords: macular pigment optical density, diabetes, central serous retinopathy, age-related macular degeneration
format	article
author	Crosby-Nwaobi R Hykin P Peto T Sivaprasad S
author_facet	Crosby-Nwaobi R Hykin P Peto T Sivaprasad S
author_sort	Crosby-Nwaobi R
title	An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases
title_short	An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases
title_full	An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases
title_fullStr	An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases
title_full_unstemmed	An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases
title_sort	exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4baa0614e2074e48892c207a742fd059
work_keys_str_mv	AT crosbynwaobir anexploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases AT hykinp anexploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases AT petot anexploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases AT sivaprasads anexploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases AT crosbynwaobir exploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases AT hykinp exploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases AT petot exploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases AT sivaprasads exploratorystudyevaluatingtheeffectsofmacularcarotenoidsupplementationinvariousretinaldiseases
_version_	1718399929818284032

An exploratory study evaluating the effects of macular carotenoid supplementation in various retinal diseases

Ejemplares similares