Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to prom...

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Autores principales: Ann-Na Cho, Yoonhee Jin, Yeonjoo An, Jin Kim, Yi Sun Choi, Jung Seung Lee, Junghoon Kim, Won-Young Choi, Dong-Jun Koo, Weonjin Yu, Gyeong-Eon Chang, Dong-Yoon Kim, Sung-Hyun Jo, Jihun Kim, Sung-Yon Kim, Yun-Gon Kim, Ju Young Kim, Nakwon Choi, Eunji Cheong, Young-Joon Kim, Hyunsoo Shawn Je, Hoon-Chul Kang, Seung-Woo Cho
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4baaa6ea520348a5bdc13ee2f2a1412c
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spelling oai:doaj.org-article:4baaa6ea520348a5bdc13ee2f2a1412c2021-12-02T18:49:37ZMicrofluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids10.1038/s41467-021-24775-52041-1723https://doaj.org/article/4baaa6ea520348a5bdc13ee2f2a1412c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24775-5https://doaj.org/toc/2041-1723Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.Ann-Na ChoYoonhee JinYeonjoo AnJin KimYi Sun ChoiJung Seung LeeJunghoon KimWon-Young ChoiDong-Jun KooWeonjin YuGyeong-Eon ChangDong-Yoon KimSung-Hyun JoJihun KimSung-Yon KimYun-Gon KimJu Young KimNakwon ChoiEunji CheongYoung-Joon KimHyunsoo Shawn JeHoon-Chul KangSeung-Woo ChoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ann-Na Cho
Yoonhee Jin
Yeonjoo An
Jin Kim
Yi Sun Choi
Jung Seung Lee
Junghoon Kim
Won-Young Choi
Dong-Jun Koo
Weonjin Yu
Gyeong-Eon Chang
Dong-Yoon Kim
Sung-Hyun Jo
Jihun Kim
Sung-Yon Kim
Yun-Gon Kim
Ju Young Kim
Nakwon Choi
Eunji Cheong
Young-Joon Kim
Hyunsoo Shawn Je
Hoon-Chul Kang
Seung-Woo Cho
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
description Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.
format article
author Ann-Na Cho
Yoonhee Jin
Yeonjoo An
Jin Kim
Yi Sun Choi
Jung Seung Lee
Junghoon Kim
Won-Young Choi
Dong-Jun Koo
Weonjin Yu
Gyeong-Eon Chang
Dong-Yoon Kim
Sung-Hyun Jo
Jihun Kim
Sung-Yon Kim
Yun-Gon Kim
Ju Young Kim
Nakwon Choi
Eunji Cheong
Young-Joon Kim
Hyunsoo Shawn Je
Hoon-Chul Kang
Seung-Woo Cho
author_facet Ann-Na Cho
Yoonhee Jin
Yeonjoo An
Jin Kim
Yi Sun Choi
Jung Seung Lee
Junghoon Kim
Won-Young Choi
Dong-Jun Koo
Weonjin Yu
Gyeong-Eon Chang
Dong-Yoon Kim
Sung-Hyun Jo
Jihun Kim
Sung-Yon Kim
Yun-Gon Kim
Ju Young Kim
Nakwon Choi
Eunji Cheong
Young-Joon Kim
Hyunsoo Shawn Je
Hoon-Chul Kang
Seung-Woo Cho
author_sort Ann-Na Cho
title Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
title_short Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
title_full Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
title_fullStr Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
title_full_unstemmed Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
title_sort microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4baaa6ea520348a5bdc13ee2f2a1412c
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