Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to prom...
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Nature Portfolio
2021
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oai:doaj.org-article:4baaa6ea520348a5bdc13ee2f2a1412c2021-12-02T18:49:37ZMicrofluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids10.1038/s41467-021-24775-52041-1723https://doaj.org/article/4baaa6ea520348a5bdc13ee2f2a1412c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24775-5https://doaj.org/toc/2041-1723Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.Ann-Na ChoYoonhee JinYeonjoo AnJin KimYi Sun ChoiJung Seung LeeJunghoon KimWon-Young ChoiDong-Jun KooWeonjin YuGyeong-Eon ChangDong-Yoon KimSung-Hyun JoJihun KimSung-Yon KimYun-Gon KimJu Young KimNakwon ChoiEunji CheongYoung-Joon KimHyunsoo Shawn JeHoon-Chul KangSeung-Woo ChoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-23 (2021) |
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Science Q Ann-Na Cho Yoonhee Jin Yeonjoo An Jin Kim Yi Sun Choi Jung Seung Lee Junghoon Kim Won-Young Choi Dong-Jun Koo Weonjin Yu Gyeong-Eon Chang Dong-Yoon Kim Sung-Hyun Jo Jihun Kim Sung-Yon Kim Yun-Gon Kim Ju Young Kim Nakwon Choi Eunji Cheong Young-Joon Kim Hyunsoo Shawn Je Hoon-Chul Kang Seung-Woo Cho Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids |
description |
Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids. |
format |
article |
author |
Ann-Na Cho Yoonhee Jin Yeonjoo An Jin Kim Yi Sun Choi Jung Seung Lee Junghoon Kim Won-Young Choi Dong-Jun Koo Weonjin Yu Gyeong-Eon Chang Dong-Yoon Kim Sung-Hyun Jo Jihun Kim Sung-Yon Kim Yun-Gon Kim Ju Young Kim Nakwon Choi Eunji Cheong Young-Joon Kim Hyunsoo Shawn Je Hoon-Chul Kang Seung-Woo Cho |
author_facet |
Ann-Na Cho Yoonhee Jin Yeonjoo An Jin Kim Yi Sun Choi Jung Seung Lee Junghoon Kim Won-Young Choi Dong-Jun Koo Weonjin Yu Gyeong-Eon Chang Dong-Yoon Kim Sung-Hyun Jo Jihun Kim Sung-Yon Kim Yun-Gon Kim Ju Young Kim Nakwon Choi Eunji Cheong Young-Joon Kim Hyunsoo Shawn Je Hoon-Chul Kang Seung-Woo Cho |
author_sort |
Ann-Na Cho |
title |
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids |
title_short |
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids |
title_full |
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids |
title_fullStr |
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids |
title_full_unstemmed |
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids |
title_sort |
microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/4baaa6ea520348a5bdc13ee2f2a1412c |
work_keys_str_mv |
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