Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice

Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice

Abstract Physical activity is known as an effective strategy for prevention and treatment of Type 2 Diabetes. The aim of this work was to compare the effects of a traditional Moderate Intensity Continuous Training (MICT) with a High Intensity Interval Training (HIIT) on glucose metabolism and mitoch...

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Autores principales: Vivien Chavanelle, Nathalie Boisseau, Yolanda F Otero, Lydie Combaret, Dominique Dardevet, Christophe Montaurier, Geoffrey Delcros, Sébastien L Peltier, Pascal Sirvent
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4bae654d0607459e8cd352e039c0f1e2
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spelling oai:doaj.org-article:4bae654d0607459e8cd352e039c0f1e22021-12-02T16:08:22ZEffects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice10.1038/s41598-017-00276-82045-2322https://doaj.org/article/4bae654d0607459e8cd352e039c0f1e22017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00276-8https://doaj.org/toc/2045-2322Abstract Physical activity is known as an effective strategy for prevention and treatment of Type 2 Diabetes. The aim of this work was to compare the effects of a traditional Moderate Intensity Continuous Training (MICT) with a High Intensity Interval Training (HIIT) on glucose metabolism and mitochondrial function in diabetic mice. Diabetic db/db male mice (N = 25) aged 6 weeks were subdivided into MICT, HIIT or control (CON) group. Animals in the training groups ran on a treadmill 5 days/week during 10 weeks. MICT group ran for 80 min (0° slope) at 50–60% of maximal speed (Vmax) reached during an incremental test. HIIT group ran thirteen times 4 minutes (20° slope) at 85–90% of Vmax separated by 2-min-rest periods. HIIT lowered fasting glycaemia and HbA1c compared with CON group (p < 0.05). In all mitochondrial function markers assessed, no differences were noted between the three groups except for total amount of electron transport chain proteins, slightly increased in the HIIT group vs CON. Western blot analysis revealed a significant increase of muscle Glut4 content (about 2 fold) and higher insulin-stimulated Akt phosphorylation ratios in HIIT group. HIIT seems to improve glucose metabolism more efficiently than MICT in diabetic mice by mechanisms independent of mitochondrial adaptations.Vivien ChavanelleNathalie BoisseauYolanda F OteroLydie CombaretDominique DardevetChristophe MontaurierGeoffrey DelcrosSébastien L PeltierPascal SirventNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Vivien Chavanelle
Nathalie Boisseau
Yolanda F Otero
Lydie Combaret
Dominique Dardevet
Christophe Montaurier
Geoffrey Delcros
Sébastien L Peltier
Pascal Sirvent
Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice
description Abstract Physical activity is known as an effective strategy for prevention and treatment of Type 2 Diabetes. The aim of this work was to compare the effects of a traditional Moderate Intensity Continuous Training (MICT) with a High Intensity Interval Training (HIIT) on glucose metabolism and mitochondrial function in diabetic mice. Diabetic db/db male mice (N = 25) aged 6 weeks were subdivided into MICT, HIIT or control (CON) group. Animals in the training groups ran on a treadmill 5 days/week during 10 weeks. MICT group ran for 80 min (0° slope) at 50–60% of maximal speed (Vmax) reached during an incremental test. HIIT group ran thirteen times 4 minutes (20° slope) at 85–90% of Vmax separated by 2-min-rest periods. HIIT lowered fasting glycaemia and HbA1c compared with CON group (p < 0.05). In all mitochondrial function markers assessed, no differences were noted between the three groups except for total amount of electron transport chain proteins, slightly increased in the HIIT group vs CON. Western blot analysis revealed a significant increase of muscle Glut4 content (about 2 fold) and higher insulin-stimulated Akt phosphorylation ratios in HIIT group. HIIT seems to improve glucose metabolism more efficiently than MICT in diabetic mice by mechanisms independent of mitochondrial adaptations.
format article
author Vivien Chavanelle
Nathalie Boisseau
Yolanda F Otero
Lydie Combaret
Dominique Dardevet
Christophe Montaurier
Geoffrey Delcros
Sébastien L Peltier
Pascal Sirvent
author_facet Vivien Chavanelle
Nathalie Boisseau
Yolanda F Otero
Lydie Combaret
Dominique Dardevet
Christophe Montaurier
Geoffrey Delcros
Sébastien L Peltier
Pascal Sirvent
author_sort Vivien Chavanelle
title Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice
title_short Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice
title_full Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice
title_fullStr Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice
title_full_unstemmed Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice
title_sort effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/4bae654d0607459e8cd352e039c0f1e2
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