COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.

Catechol-O-methyltransferase (COMT) plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity asso...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dennis Hernaus, Dina Collip, Johan Lataster, Jenny Ceccarini, Gunther Kenis, Linda Booij, Jens Pruessner, Koen Van Laere, Ruud van Winkel, Jim van Os, Inez Myin-Germeys
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4bafb1ba0702412096355f4e8a5a19b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4bafb1ba0702412096355f4e8a5a19b0
record_format	dspace
spelling	oai:doaj.org-article:4bafb1ba0702412096355f4e8a5a19b02021-11-18T07:41:42ZCOMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.1932-620310.1371/journal.pone.0065662https://doaj.org/article/4bafb1ba0702412096355f4e8a5a19b02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23799032/?tool=EBIhttps://doaj.org/toc/1932-6203Catechol-O-methyltransferase (COMT) plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. We aimed to investigate the effect of variations in COMT genotype on in vivo measures of stress-induced prefrontal cortex (PFC) dopaminergic processing and subjective stress responses. A combined sample of healthy controls and healthy first-degree relatives of psychosis patients (n = 26) were subjected to an [(18)F]fallypride Positron Emission Tomography scan. Psychosocial stress during the scan was induced using the Montreal Imaging Stress Task and subjective stress was assessed every 12 minutes. Parametric t-maps, generated using the linear extension of the simplified reference region model, revealed an effect of COMT genotype on the spatial extent of [(18)F]fallypride displacement. Detected effects of exposure to psychosocial stress were unilateral and remained restricted to the left superior and right inferior frontal gyrus, with Met-hetero- and homozygotes showing less [(18)F]fallypride displacement than Val-homozygotes. Additionally, Met-hetero- and homozygotes experienced larger subjective stress responses than Val-homozygotes. The direction of the effects remained the same when the data was analyzed separately for controls and first-degree relatives. The human stress response may be mediated in part by COMT-dependent dopaminergic PFC activity, providing speculation for the neurobiology underlying COMT-dependent differences in human behaviour following stress. Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed.Dennis HernausDina CollipJohan LatasterJenny CeccariniGunther KenisLinda BooijJens PruessnerKoen Van LaereRuud van WinkelJim van OsInez Myin-GermeysPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65662 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dennis Hernaus Dina Collip Johan Lataster Jenny Ceccarini Gunther Kenis Linda Booij Jens Pruessner Koen Van Laere Ruud van Winkel Jim van Os Inez Myin-Germeys COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
description	Catechol-O-methyltransferase (COMT) plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. We aimed to investigate the effect of variations in COMT genotype on in vivo measures of stress-induced prefrontal cortex (PFC) dopaminergic processing and subjective stress responses. A combined sample of healthy controls and healthy first-degree relatives of psychosis patients (n = 26) were subjected to an [(18)F]fallypride Positron Emission Tomography scan. Psychosocial stress during the scan was induced using the Montreal Imaging Stress Task and subjective stress was assessed every 12 minutes. Parametric t-maps, generated using the linear extension of the simplified reference region model, revealed an effect of COMT genotype on the spatial extent of [(18)F]fallypride displacement. Detected effects of exposure to psychosocial stress were unilateral and remained restricted to the left superior and right inferior frontal gyrus, with Met-hetero- and homozygotes showing less [(18)F]fallypride displacement than Val-homozygotes. Additionally, Met-hetero- and homozygotes experienced larger subjective stress responses than Val-homozygotes. The direction of the effects remained the same when the data was analyzed separately for controls and first-degree relatives. The human stress response may be mediated in part by COMT-dependent dopaminergic PFC activity, providing speculation for the neurobiology underlying COMT-dependent differences in human behaviour following stress. Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed.
format	article
author	Dennis Hernaus Dina Collip Johan Lataster Jenny Ceccarini Gunther Kenis Linda Booij Jens Pruessner Koen Van Laere Ruud van Winkel Jim van Os Inez Myin-Germeys
author_facet	Dennis Hernaus Dina Collip Johan Lataster Jenny Ceccarini Gunther Kenis Linda Booij Jens Pruessner Koen Van Laere Ruud van Winkel Jim van Os Inez Myin-Germeys
author_sort	Dennis Hernaus
title	COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
title_short	COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
title_full	COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
title_fullStr	COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
title_full_unstemmed	COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
title_sort	comt val158met genotype selectively alters prefrontal [18f]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4bafb1ba0702412096355f4e8a5a19b0
work_keys_str_mv	AT dennishernaus comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT dinacollip comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT johanlataster comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT jennyceccarini comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT guntherkenis comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT lindabooij comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT jenspruessner comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT koenvanlaere comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT ruudvanwinkel comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT jimvanos comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge AT inezmyingermeys comtval158metgenotypeselectivelyaltersprefrontal18ffallypridedisplacementandsubjectivefeelingsofstressinresponsetoapsychosocialstresschallenge
_version_	1718423095525507072

COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.

Ejemplares similares