COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.

COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.

Catechol-O-methyltransferase (COMT) plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity asso...

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Autores principales: Dennis Hernaus, Dina Collip, Johan Lataster, Jenny Ceccarini, Gunther Kenis, Linda Booij, Jens Pruessner, Koen Van Laere, Ruud van Winkel, Jim van Os, Inez Myin-Germeys
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/4bafb1ba0702412096355f4e8a5a19b0
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