Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging

Abstract Plasma noradrenaline levels increase with aging, and this could contribute to the sympathetic overactivity that is associated with essential hypertension and the metabolic syndrome. The underlying cause of this rise in noradrenaline is unknown, but a clue may be that mercury increases norad...

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Autores principales:	Roger Pamphlett, Stephen Kum Jew, Philip A. Doble, David P. Bishop
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4bafc16cf0ee4c8fb48e8771ad47a7c3
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spelling	oai:doaj.org-article:4bafc16cf0ee4c8fb48e8771ad47a7c32021-12-02T14:06:24ZMercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging10.1038/s41598-021-82483-y2045-2322https://doaj.org/article/4bafc16cf0ee4c8fb48e8771ad47a7c32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82483-yhttps://doaj.org/toc/2045-2322Abstract Plasma noradrenaline levels increase with aging, and this could contribute to the sympathetic overactivity that is associated with essential hypertension and the metabolic syndrome. The underlying cause of this rise in noradrenaline is unknown, but a clue may be that mercury increases noradrenaline output from the adrenal medulla of experimental animals. We therefore determined the proportion of people from 2 to 104 years of age who had mercury in their adrenal medulla. Mercury was detected in paraffin sections of autopsied adrenal glands using two methods of elemental bioimaging, autometallography and laser ablation-inductively coupled plasma-mass spectrometry. Mercury first appeared in cells of the adrenal medulla in the 21–40 years group, where it was present in 52% of samples, and increased progressively in frequency in older age groups, until it was detected in 90% of samples from people aged over 80 years. In conclusion, the proportion of people having mercury in their adrenal medulla increases with aging. Mercury could alter the metabolism of catecholamines in the adrenal medulla that leads to the raised levels of plasma noradrenaline in aging. This retrospective autopsy study was not able to provide a definitive link between adrenal mercury, noradrenaline levels and hypertension, but future functional human and experimental studies could provide further evidence for these associations.Roger PamphlettStephen Kum JewPhilip A. DobleDavid P. BishopNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roger Pamphlett Stephen Kum Jew Philip A. Doble David P. Bishop Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
description	Abstract Plasma noradrenaline levels increase with aging, and this could contribute to the sympathetic overactivity that is associated with essential hypertension and the metabolic syndrome. The underlying cause of this rise in noradrenaline is unknown, but a clue may be that mercury increases noradrenaline output from the adrenal medulla of experimental animals. We therefore determined the proportion of people from 2 to 104 years of age who had mercury in their adrenal medulla. Mercury was detected in paraffin sections of autopsied adrenal glands using two methods of elemental bioimaging, autometallography and laser ablation-inductively coupled plasma-mass spectrometry. Mercury first appeared in cells of the adrenal medulla in the 21–40 years group, where it was present in 52% of samples, and increased progressively in frequency in older age groups, until it was detected in 90% of samples from people aged over 80 years. In conclusion, the proportion of people having mercury in their adrenal medulla increases with aging. Mercury could alter the metabolism of catecholamines in the adrenal medulla that leads to the raised levels of plasma noradrenaline in aging. This retrospective autopsy study was not able to provide a definitive link between adrenal mercury, noradrenaline levels and hypertension, but future functional human and experimental studies could provide further evidence for these associations.
format	article
author	Roger Pamphlett Stephen Kum Jew Philip A. Doble David P. Bishop
author_facet	Roger Pamphlett Stephen Kum Jew Philip A. Doble David P. Bishop
author_sort	Roger Pamphlett
title	Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
title_short	Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
title_full	Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
title_fullStr	Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
title_full_unstemmed	Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
title_sort	mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4bafc16cf0ee4c8fb48e8771ad47a7c3
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Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging

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