DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS

Abstract. The aim of this study was to detect some features of autoreactive IgM production that interact with IgGs and normal human cellular antigens in blood sera of patients with acute respiratory viral infections caused by various factors, dependent on their age and clinical features of disease....

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Autores principales:	V. Z. Krivitskaya, M. V. Sverlova, V. F. Sukhovetskaya, N. I. Lvov, I. A. Vassilieva, A. A. Sominina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoreactive igm acute respiratory viral infections children adult patients Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4bb1d317a3ca40718d4b843ac7edf880
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spelling	oai:doaj.org-article:4bb1d317a3ca40718d4b843ac7edf8802021-11-18T08:03:38ZDETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS1563-06252313-741X10.15789/1563-0625-2008-2-3-229-238https://doaj.org/article/4bb1d317a3ca40718d4b843ac7edf8802014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/153https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of this study was to detect some features of autoreactive IgM production that interact with IgGs and normal human cellular antigens in blood sera of patients with acute respiratory viral infections caused by various factors, dependent on their age and clinical features of disease. The antibody concentrations were determined by immunoenzyme technique in paired serum samples from 750 patients and single specimens from 97 healthy persons. The results of analysis have shown that the studied types of autoreactive IgM represent a normal component of humoral immunity, since they are detectable in sufficient number of normal sera from healthy persons over 3 years old. In acute respiratory viral infections of different etiology, the rates of appropriate seroconversions comprised 0 to 16% for age cohort of < 3 years old. Incidence of seroconversions reached 37% among older children and adult patients with respiratory syncitial virus (RSV), or adenoviral infection, thus being 1.7 to 5.1-fold higher than in patients with influenza A, or B, or parainfluenza. In cases of clinical complications of RSV or parainfluenza infections (i.e., respiratory tract obstruction, or pneumonia), the rates of seroconversions to autoreactive IgMs was 1.4 to1.8-fold higher than among the patients with uncomplicated clinical course of these infections. (Med. Immunol., 2008, vol. 10, N 2-3, pp 229-238).V. Z. KrivitskayaM. V. SverlovaV. F. SukhovetskayaN. I. LvovI. A. VassilievaA. A. SomininaSPb RAACIarticleautoreactive igmacute respiratory viral infectionschildrenadult patientsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 229-238 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoreactive igm acute respiratory viral infections children adult patients Immunologic diseases. Allergy RC581-607
spellingShingle	autoreactive igm acute respiratory viral infections children adult patients Immunologic diseases. Allergy RC581-607 V. Z. Krivitskaya M. V. Sverlova V. F. Sukhovetskaya N. I. Lvov I. A. Vassilieva A. A. Sominina DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
description	Abstract. The aim of this study was to detect some features of autoreactive IgM production that interact with IgGs and normal human cellular antigens in blood sera of patients with acute respiratory viral infections caused by various factors, dependent on their age and clinical features of disease. The antibody concentrations were determined by immunoenzyme technique in paired serum samples from 750 patients and single specimens from 97 healthy persons. The results of analysis have shown that the studied types of autoreactive IgM represent a normal component of humoral immunity, since they are detectable in sufficient number of normal sera from healthy persons over 3 years old. In acute respiratory viral infections of different etiology, the rates of appropriate seroconversions comprised 0 to 16% for age cohort of < 3 years old. Incidence of seroconversions reached 37% among older children and adult patients with respiratory syncitial virus (RSV), or adenoviral infection, thus being 1.7 to 5.1-fold higher than in patients with influenza A, or B, or parainfluenza. In cases of clinical complications of RSV or parainfluenza infections (i.e., respiratory tract obstruction, or pneumonia), the rates of seroconversions to autoreactive IgMs was 1.4 to1.8-fold higher than among the patients with uncomplicated clinical course of these infections. (Med. Immunol., 2008, vol. 10, N 2-3, pp 229-238).
format	article
author	V. Z. Krivitskaya M. V. Sverlova V. F. Sukhovetskaya N. I. Lvov I. A. Vassilieva A. A. Sominina
author_facet	V. Z. Krivitskaya M. V. Sverlova V. F. Sukhovetskaya N. I. Lvov I. A. Vassilieva A. A. Sominina
author_sort	V. Z. Krivitskaya
title	DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
title_short	DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
title_full	DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
title_fullStr	DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
title_full_unstemmed	DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS
title_sort	detection of autoreactive class m antibodies in patients with respiratory viral infections
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/4bb1d317a3ca40718d4b843ac7edf880
work_keys_str_mv	AT vzkrivitskaya detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT mvsverlova detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT vfsukhovetskaya detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT nilvov detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT iavassilieva detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections AT aasominina detectionofautoreactiveclassmantibodiesinpatientswithrespiratoryviralinfections
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DETECTION OF AUTOREACTIVE CLASS M ANTIBODIES IN PATIENTS WITH RESPIRATORY VIRAL INFECTIONS

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