Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

Maged Sayed Ahmad,1 Manal Mohamed Yasser,1 Essam Nageh Sholkamy,1,2 Ali Mohamed Ali,3,4 Magda Mohamed Mehanni3 1Department of Botany, Faculty of Science, University of Beni-Suef, Beni-Suef, Egypt; 2Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia...

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Autores principales:	Ahmad MS, Yasser MM, Sholkamy EN, Ali AM, Mehanni MM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4bb61616d88f4983a407bd367cca601e
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spelling	oai:doaj.org-article:4bb61616d88f4983a407bd367cca601e2021-12-02T05:10:26ZAnticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-11178-2013https://doaj.org/article/4bb61616d88f4983a407bd367cca601e2015-05-01T00:00:00Zhttp://www.dovepress.com/anticancer-activity-of-biostabilized-selenium-nanorods-synthesized-by--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Maged Sayed Ahmad,1 Manal Mohamed Yasser,1 Essam Nageh Sholkamy,1,2 Ali Mohamed Ali,3,4 Magda Mohamed Mehanni3 1Department of Botany, Faculty of Science, University of Beni-Suef, Beni-Suef, Egypt; 2Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Department of Botany and Microbiology, College of Science, Minia University, El-Minia, Egypt; 4Department of Biological Sciences, College of Science, King Faisal University, Saudi Arabia Abstract: Selenium is an important component of human diet and a number of studies have declared its chemopreventive and therapeutic properties against cancer. However, very limited studies have been conducted about the properties of selenium nanostructured materials in comparison to other well-studied selenospecies. Here, we have shown that the anticancer property of biostabilized selenium nanorods (SeNrs) synthesized by applying a novel strain Ess_amA-1 of Streptomyces bikiniensis. The strain was grown aerobically with selenium dioxide and produced stable SeNrs with average particle size of 17 nm. The optical, structural, morphological, elemental, and functional characterizations of the SeNrs were carried out using techniques such as UV-vis spectrophotometry, transmission electron microscopy, energy dispersive X-ray spectrometry, and Fourier transform infrared spectrophotometry, respectively. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed that the biosynthesized SeNrs induces cell death of Hep-G2 and MCF-7 human cancer cells. The lethal dose (LD50%) of SeNrs on Hep-G2 and MCF-7 cells was recorded at 75.96 µg/mL and 61.86 µg/mL, respectively. It can be concluded that S. bikiniensis strain Ess_amA-1 could be used as renewable bioresources of biosynthesis of anticancer SeNrs. A hypothetical mechanism for anticancer activity of SeNrs is also proposed. Keywords: biosynthesis, selenium nanorods, Streptomyces, anticancer activityAhmad MSYasser MMSholkamy ENAli AMMehanni MMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3389-3401 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ahmad MS Yasser MM Sholkamy EN Ali AM Mehanni MM Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1
description	Maged Sayed Ahmad,1 Manal Mohamed Yasser,1 Essam Nageh Sholkamy,1,2 Ali Mohamed Ali,3,4 Magda Mohamed Mehanni3 1Department of Botany, Faculty of Science, University of Beni-Suef, Beni-Suef, Egypt; 2Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Department of Botany and Microbiology, College of Science, Minia University, El-Minia, Egypt; 4Department of Biological Sciences, College of Science, King Faisal University, Saudi Arabia Abstract: Selenium is an important component of human diet and a number of studies have declared its chemopreventive and therapeutic properties against cancer. However, very limited studies have been conducted about the properties of selenium nanostructured materials in comparison to other well-studied selenospecies. Here, we have shown that the anticancer property of biostabilized selenium nanorods (SeNrs) synthesized by applying a novel strain Ess_amA-1 of Streptomyces bikiniensis. The strain was grown aerobically with selenium dioxide and produced stable SeNrs with average particle size of 17 nm. The optical, structural, morphological, elemental, and functional characterizations of the SeNrs were carried out using techniques such as UV-vis spectrophotometry, transmission electron microscopy, energy dispersive X-ray spectrometry, and Fourier transform infrared spectrophotometry, respectively. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed that the biosynthesized SeNrs induces cell death of Hep-G2 and MCF-7 human cancer cells. The lethal dose (LD50%) of SeNrs on Hep-G2 and MCF-7 cells was recorded at 75.96 µg/mL and 61.86 µg/mL, respectively. It can be concluded that S. bikiniensis strain Ess_amA-1 could be used as renewable bioresources of biosynthesis of anticancer SeNrs. A hypothetical mechanism for anticancer activity of SeNrs is also proposed. Keywords: biosynthesis, selenium nanorods, Streptomyces, anticancer activity
format	article
author	Ahmad MS Yasser MM Sholkamy EN Ali AM Mehanni MM
author_facet	Ahmad MS Yasser MM Sholkamy EN Ali AM Mehanni MM
author_sort	Ahmad MS
title	Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1
title_short	Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1
title_full	Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1
title_fullStr	Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1
title_full_unstemmed	Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1
title_sort	anticancer activity of biostabilized selenium nanorods synthesized by streptomyces bikiniensis strain ess_ama-1
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/4bb61616d88f4983a407bd367cca601e
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Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

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