The development of the posterity of male and female outbred rats exposed to sublimate
Mercury has gonadotropic and mutagenic effects on the Mammalia organism. This fact indicates the possibility of appearance of the mercury exposure effects on the offspring whose parents were exposed to this toxicant. The sublimate effects on the development of the first generation offspring from mal...
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| Formato: | article |
| Lenguaje: | RU |
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Scientific Сentre for Family Health and Human Reproduction Problems
2013
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/4bb66290b6ff406c8403c5b1b15ecda1 |
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| Sumario: | Mercury has gonadotropic and mutagenic effects on the Mammalia organism. This fact indicates the possibility of appearance of the mercury exposure effects on the offspring whose parents were exposed to this toxicant. The sublimate effects on the development of the first generation offspring from male and female outbred rats exposed to this substance were studied. Sublimate solution. (0,05 mg of mercury for 100 g of animal's body weight) was injected subcutaneously to outbred rats during 6 weeks. After ending of the injections these rats were mated with intact rats for getting the posterity. The examination of albino rats posterity had two stages. The first stage was to study the development of sensor-motional reactions on the first and. the tenth days of life. The second stage included the research of zoosocial behavior of sexually mature rats and. their activity in open field. Also the posterity was weighted for estimation of physical development. Obtained, materials of the researches were elaborated with use of methods of nonparametric statistics (Mann — Whitney U-criteria). At the analysis of the results of the experiment we revealed statistically significant differences in body weight and. motive activity of animals of experimental group in comparison with control group. Decrease of body weight in posterity of experimental male rats was revealed and. there were no differences in maturation of sensor-motional reflexes in their first days of life. Increase of body weight and motional activity was revealed in posterity of female rats with sublimate intoxication in comparison with control values. Changes of body weight and. behavior were registered in sexually mature posterity. Increase of body weight in comparison with control group was registered at the weighing of experimental animals. Depression of motive, position-finding, research and zoosocial activity was revealed in posterity of experimental male rats. Depression of motive, position-finding and. research activity was revealed in male posterity of experimental female rats and. strengthening of position-finding and. research activity was revealed in their female posterity. |
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