HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function, results in secretase-dependent Aβ production a...

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Autores principales:	Qingqing Chai, Vladimir Jovasevic, Viacheslav Malikov, Yosef Sabo, Scott Morham, Derek Walsh, Mojgan H. Naghavi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bb6852761304008b18756776bcceede
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spelling	oai:doaj.org-article:4bb6852761304008b18756776bcceede2021-12-02T17:01:21ZHIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration10.1038/s41467-017-01795-82041-1723https://doaj.org/article/4bb6852761304008b18756776bcceede2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01795-8https://doaj.org/toc/2041-1723HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function, results in secretase-dependent Aβ production and neuron degeneration.Qingqing ChaiVladimir JovasevicViacheslav MalikovYosef SaboScott MorhamDerek WalshMojgan H. NaghaviNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingqing Chai Vladimir Jovasevic Viacheslav Malikov Yosef Sabo Scott Morham Derek Walsh Mojgan H. Naghavi HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
description	HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function, results in secretase-dependent Aβ production and neuron degeneration.
format	article
author	Qingqing Chai Vladimir Jovasevic Viacheslav Malikov Yosef Sabo Scott Morham Derek Walsh Mojgan H. Naghavi
author_facet	Qingqing Chai Vladimir Jovasevic Viacheslav Malikov Yosef Sabo Scott Morham Derek Walsh Mojgan H. Naghavi
author_sort	Qingqing Chai
title	HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
title_short	HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
title_full	HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
title_fullStr	HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
title_full_unstemmed	HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
title_sort	hiv-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4bb6852761304008b18756776bcceede
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HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

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