Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer

Worldwide, cancer is the second leading cause of mortality after cardiovascular diseases. Among the numerous malignant tumors in human, digestive system cancers are the primary cause of morbidity and mortality. Acetylation and deacetylation are crucially involved in cancer occurrence and development...

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Autores principales:	Bingyi Zhou, Deliang Liu, Yuyong Tan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	histone deacetylases histone deacetylase inhibitor gastrointestinal cancer deacetylation ubiquitination Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4bba92dba64941db88bd778c548d3f1b
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id	oai:doaj.org-article:4bba92dba64941db88bd778c548d3f1b
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spelling	oai:doaj.org-article:4bba92dba64941db88bd778c548d3f1b2021-12-02T11:39:19ZRole of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer2296-634X10.3389/fcell.2021.719390https://doaj.org/article/4bba92dba64941db88bd778c548d3f1b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.719390/fullhttps://doaj.org/toc/2296-634XWorldwide, cancer is the second leading cause of mortality after cardiovascular diseases. Among the numerous malignant tumors in human, digestive system cancers are the primary cause of morbidity and mortality. Acetylation and deacetylation are crucially involved in cancer occurrence and development; in addition, the deacetylation process is regulated by histone deacetylases (HDACs). Among the 18 human HDACs that have been reported, HDAC6 has been widely studied. There is upregulated HDAC6 expression in numerous types of tumor tissues and is closely associated with clinicopathological characteristics. Moreover, several HDAC6 inhibitors have been identified; furthermore, there has been extensive research on their ability to inhibit the growth of many tumors. This review summarizes the roles of HDAC6 in different primary digestive system malignancies.Bingyi ZhouBingyi ZhouDeliang LiuDeliang LiuYuyong TanYuyong TanFrontiers Media S.A.articlehistone deacetylaseshistone deacetylase inhibitorgastrointestinal cancerdeacetylationubiquitinationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	histone deacetylases histone deacetylase inhibitor gastrointestinal cancer deacetylation ubiquitination Biology (General) QH301-705.5
spellingShingle	histone deacetylases histone deacetylase inhibitor gastrointestinal cancer deacetylation ubiquitination Biology (General) QH301-705.5 Bingyi Zhou Bingyi Zhou Deliang Liu Deliang Liu Yuyong Tan Yuyong Tan Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer
description	Worldwide, cancer is the second leading cause of mortality after cardiovascular diseases. Among the numerous malignant tumors in human, digestive system cancers are the primary cause of morbidity and mortality. Acetylation and deacetylation are crucially involved in cancer occurrence and development; in addition, the deacetylation process is regulated by histone deacetylases (HDACs). Among the 18 human HDACs that have been reported, HDAC6 has been widely studied. There is upregulated HDAC6 expression in numerous types of tumor tissues and is closely associated with clinicopathological characteristics. Moreover, several HDAC6 inhibitors have been identified; furthermore, there has been extensive research on their ability to inhibit the growth of many tumors. This review summarizes the roles of HDAC6 in different primary digestive system malignancies.
format	article
author	Bingyi Zhou Bingyi Zhou Deliang Liu Deliang Liu Yuyong Tan Yuyong Tan
author_facet	Bingyi Zhou Bingyi Zhou Deliang Liu Deliang Liu Yuyong Tan Yuyong Tan
author_sort	Bingyi Zhou
title	Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer
title_short	Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer
title_full	Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer
title_fullStr	Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer
title_full_unstemmed	Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer
title_sort	role of hdac6 and its selective inhibitors in gastrointestinal cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4bba92dba64941db88bd778c548d3f1b
work_keys_str_mv	AT bingyizhou roleofhdac6anditsselectiveinhibitorsingastrointestinalcancer AT bingyizhou roleofhdac6anditsselectiveinhibitorsingastrointestinalcancer AT deliangliu roleofhdac6anditsselectiveinhibitorsingastrointestinalcancer AT deliangliu roleofhdac6anditsselectiveinhibitorsingastrointestinalcancer AT yuyongtan roleofhdac6anditsselectiveinhibitorsingastrointestinalcancer AT yuyongtan roleofhdac6anditsselectiveinhibitorsingastrointestinalcancer
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Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer

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