Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.

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Autores principales:	Johannes Gregor Matthias Rack, Qiang Liu, Valentina Zorzini, Jim Voorneveld, Antonio Ariza, Kourosh Honarmand Ebrahimi, Julia M. Reber, Sarah C. Krassnig, Dragana Ahel, Gijsbert A. van der Marel, Aswin Mangerich, James S. O. McCullagh, Dmitri V. Filippov, Ivan Ahel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bbd22b00672441db09292221ae3ea22
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spelling	oai:doaj.org-article:4bbd22b00672441db09292221ae3ea222021-12-02T16:24:23ZMechanistic insights into the three steps of poly(ADP-ribosylation) reversal10.1038/s41467-021-24723-32041-1723https://doaj.org/article/4bbd22b00672441db09292221ae3ea222021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24723-3https://doaj.org/toc/2041-1723PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.Johannes Gregor Matthias RackQiang LiuValentina ZorziniJim VoorneveldAntonio ArizaKourosh Honarmand EbrahimiJulia M. ReberSarah C. KrassnigDragana AhelGijsbert A. van der MarelAswin MangerichJames S. O. McCullaghDmitri V. FilippovIvan AhelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Johannes Gregor Matthias Rack Qiang Liu Valentina Zorzini Jim Voorneveld Antonio Ariza Kourosh Honarmand Ebrahimi Julia M. Reber Sarah C. Krassnig Dragana Ahel Gijsbert A. van der Marel Aswin Mangerich James S. O. McCullagh Dmitri V. Filippov Ivan Ahel Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
description	PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.
format	article
author	Johannes Gregor Matthias Rack Qiang Liu Valentina Zorzini Jim Voorneveld Antonio Ariza Kourosh Honarmand Ebrahimi Julia M. Reber Sarah C. Krassnig Dragana Ahel Gijsbert A. van der Marel Aswin Mangerich James S. O. McCullagh Dmitri V. Filippov Ivan Ahel
author_facet	Johannes Gregor Matthias Rack Qiang Liu Valentina Zorzini Jim Voorneveld Antonio Ariza Kourosh Honarmand Ebrahimi Julia M. Reber Sarah C. Krassnig Dragana Ahel Gijsbert A. van der Marel Aswin Mangerich James S. O. McCullagh Dmitri V. Filippov Ivan Ahel
author_sort	Johannes Gregor Matthias Rack
title	Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
title_short	Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
title_full	Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
title_fullStr	Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
title_full_unstemmed	Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
title_sort	mechanistic insights into the three steps of poly(adp-ribosylation) reversal
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4bbd22b00672441db09292221ae3ea22
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Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

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