Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection

Abstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after...

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Autores principales:	Qi Wu, Lina Zhou, Xin Sun, Zhongfang Yan, Chunxiu Hu, Junping Wu, Long Xu, Xue Li, Huiling Liu, Peiyuan Yin, Kuan Li, Jieyu Zhao, Yanli Li, Xiaolin Wang, Yu Li, Qiuyang Zhang, Guowang Xu, Huaiyong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4bc09502862a4a3a98f165d9856f4c78
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spelling	oai:doaj.org-article:4bc09502862a4a3a98f165d9856f4c782021-12-02T12:32:31ZAltered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection10.1038/s41598-017-09536-z2045-2322https://doaj.org/article/4bc09502862a4a3a98f165d9856f4c782017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09536-zhttps://doaj.org/toc/2045-2322Abstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.Qi WuLina ZhouXin SunZhongfang YanChunxiu HuJunping WuLong XuXue LiHuiling LiuPeiyuan YinKuan LiJieyu ZhaoYanli LiXiaolin WangYu LiQiuyang ZhangGuowang XuHuaiyong ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qi Wu Lina Zhou Xin Sun Zhongfang Yan Chunxiu Hu Junping Wu Long Xu Xue Li Huiling Liu Peiyuan Yin Kuan Li Jieyu Zhao Yanli Li Xiaolin Wang Yu Li Qiuyang Zhang Guowang Xu Huaiyong Chen Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
description	Abstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.
format	article
author	Qi Wu Lina Zhou Xin Sun Zhongfang Yan Chunxiu Hu Junping Wu Long Xu Xue Li Huiling Liu Peiyuan Yin Kuan Li Jieyu Zhao Yanli Li Xiaolin Wang Yu Li Qiuyang Zhang Guowang Xu Huaiyong Chen
author_facet	Qi Wu Lina Zhou Xin Sun Zhongfang Yan Chunxiu Hu Junping Wu Long Xu Xue Li Huiling Liu Peiyuan Yin Kuan Li Jieyu Zhao Yanli Li Xiaolin Wang Yu Li Qiuyang Zhang Guowang Xu Huaiyong Chen
author_sort	Qi Wu
title	Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
title_short	Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
title_full	Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
title_fullStr	Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
title_full_unstemmed	Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
title_sort	altered lipid metabolism in recovered sars patients twelve years after infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4bc09502862a4a3a98f165d9856f4c78
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Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection

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