LINGO1 variants in the French-Canadian population.

LINGO1 variants in the French-Canadian population.

Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be rep...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Cynthia V Bourassa, Jean-Baptiste Rivière, Patrick A Dion, Geneviève Bernard, Sabrina Diab, Michel Panisset, Sylvain Chouinard, Nicolas Dupré, Hélène Fournier, John Raelson, Majid Belouchi, Guy A Rouleau
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/4bc29343cc0b4aab9350dd534097d709
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:4bc29343cc0b4aab9350dd534097d709
record_format dspace
spelling oai:doaj.org-article:4bc29343cc0b4aab9350dd534097d7092021-11-18T07:00:35ZLINGO1 variants in the French-Canadian population.1932-620310.1371/journal.pone.0016254https://doaj.org/article/4bc29343cc0b4aab9350dd534097d7092011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21264305/?tool=EBIhttps://doaj.org/toc/1932-6203Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).Cynthia V BourassaJean-Baptiste RivièrePatrick A DionGeneviève BernardSabrina DiabMichel PanissetSylvain ChouinardNicolas DupréHélène FournierJohn RaelsonMajid BelouchiGuy A RouleauPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e16254 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Cynthia V Bourassa
Jean-Baptiste Rivière
Patrick A Dion
Geneviève Bernard
Sabrina Diab
Michel Panisset
Sylvain Chouinard
Nicolas Dupré
Hélène Fournier
John Raelson
Majid Belouchi
Guy A Rouleau
LINGO1 variants in the French-Canadian population.
description Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).
format article
author Cynthia V Bourassa
Jean-Baptiste Rivière
Patrick A Dion
Geneviève Bernard
Sabrina Diab
Michel Panisset
Sylvain Chouinard
Nicolas Dupré
Hélène Fournier
John Raelson
Majid Belouchi
Guy A Rouleau
author_facet Cynthia V Bourassa
Jean-Baptiste Rivière
Patrick A Dion
Geneviève Bernard
Sabrina Diab
Michel Panisset
Sylvain Chouinard
Nicolas Dupré
Hélène Fournier
John Raelson
Majid Belouchi
Guy A Rouleau
author_sort Cynthia V Bourassa
title LINGO1 variants in the French-Canadian population.
title_short LINGO1 variants in the French-Canadian population.
title_full LINGO1 variants in the French-Canadian population.
title_fullStr LINGO1 variants in the French-Canadian population.
title_full_unstemmed LINGO1 variants in the French-Canadian population.
title_sort lingo1 variants in the french-canadian population.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/4bc29343cc0b4aab9350dd534097d709
work_keys_str_mv AT cynthiavbourassa lingo1variantsinthefrenchcanadianpopulation
AT jeanbaptisteriviere lingo1variantsinthefrenchcanadianpopulation
AT patrickadion lingo1variantsinthefrenchcanadianpopulation
AT genevievebernard lingo1variantsinthefrenchcanadianpopulation
AT sabrinadiab lingo1variantsinthefrenchcanadianpopulation
AT michelpanisset lingo1variantsinthefrenchcanadianpopulation
AT sylvainchouinard lingo1variantsinthefrenchcanadianpopulation
AT nicolasdupre lingo1variantsinthefrenchcanadianpopulation
AT helenefournier lingo1variantsinthefrenchcanadianpopulation
AT johnraelson lingo1variantsinthefrenchcanadianpopulation
AT majidbelouchi lingo1variantsinthefrenchcanadianpopulation
AT guyarouleau lingo1variantsinthefrenchcanadianpopulation
_version_ 1718424037581914112

Ejemplares similares