Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines

Yixing Tian, Yiming Ji, Xin Mei, Jun Pan, Wenye He, Jiajia Sun, Kaichen Wan, Huilin Yang Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Huilin Yang Email suzhouspine@163.comBackground: Inter...

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Autores principales:	Tian Y, Ji Y, Mei X, Pan J, He W, Sun J, Wan K, Yang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	intervertebral disc degeneration melatonin biomarker inflammatory factors. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/4bc32f1541c24c52807b297a9185d996
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spelling	oai:doaj.org-article:4bc32f1541c24c52807b297a9185d9962021-12-02T13:30:24ZLower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines1178-1998https://doaj.org/article/4bc32f1541c24c52807b297a9185d9962021-02-01T00:00:00Zhttps://www.dovepress.com/lower-plasma-melatonin-in-the-intervertebral-disk-degeneration-patient-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yixing Tian, Yiming Ji, Xin Mei, Jun Pan, Wenye He, Jiajia Sun, Kaichen Wan, Huilin Yang Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Huilin Yang Email suzhouspine@163.comBackground: Intervertebral disc degeneration (IDD) was considered to be the pathological basis of intervertebral disc herniation (IDH). However, the plasma melatonin in the IDD cases and healthy controls remained unclear.Methods: In this case–control study, a total of 71 IDD cases and 54 healthy controls were enrolled between April 2020 and August 2020. The diagnostic effect of plasma melatonin for IDD was detected using receiver operating characteristic curve. The correlations between two continuous variables were detected with the Pearson linear analyses.Results: It was found that lower melatonin concentration was detected in the IDD cases (1.906 ± 1.041 vs 3.072 ± 0.511 pg/mL, P< 0.001). Through receiver operating characteristic curve analyses, it was found that plasma melatonin could be used as a diagnostic biomarker for IDD (area under curve=0.808, P< 0.001). In advanced correlation analyses, it was found that plasma melatonin concentration was negatively associated with the age, symptom durations, IDD disease severity and proinflammatory factors, including IL-6 and TNF-α concentrations (P< 0.05). Comparing with the higher melatonin groups, significantly increased IL-6 (0.601 ± 0.085 vs 0.507 ± 0.167 pg/mL, P=0.028) and TNF-α (3.022 ± 0.286 vs 2.353 ± 0.641, P< 0.001) were detected in the patients with lower melatonin concentration.Conclusion: The plasma melatonin concentration was significantly decreased in the IDD cases and plasma melatonin could be used as a diagnostic biomarker for IDD. Lower plasma melatonin was associated with longer disease durations, elevated disease severity and higher inflammatory cytokines levels in IDD patients.Keywords: intervertebral disc degeneration, melatonin, biomarker, inflammatory factorsTian YJi YMei XPan JHe WSun JWan KYang HDove Medical Pressarticleintervertebral disc degenerationmelatoninbiomarkerinflammatory factors.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 215-224 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intervertebral disc degeneration melatonin biomarker inflammatory factors. Geriatrics RC952-954.6
spellingShingle	intervertebral disc degeneration melatonin biomarker inflammatory factors. Geriatrics RC952-954.6 Tian Y Ji Y Mei X Pan J He W Sun J Wan K Yang H Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines
description	Yixing Tian, Yiming Ji, Xin Mei, Jun Pan, Wenye He, Jiajia Sun, Kaichen Wan, Huilin Yang Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Huilin Yang Email suzhouspine@163.comBackground: Intervertebral disc degeneration (IDD) was considered to be the pathological basis of intervertebral disc herniation (IDH). However, the plasma melatonin in the IDD cases and healthy controls remained unclear.Methods: In this case–control study, a total of 71 IDD cases and 54 healthy controls were enrolled between April 2020 and August 2020. The diagnostic effect of plasma melatonin for IDD was detected using receiver operating characteristic curve. The correlations between two continuous variables were detected with the Pearson linear analyses.Results: It was found that lower melatonin concentration was detected in the IDD cases (1.906 ± 1.041 vs 3.072 ± 0.511 pg/mL, P< 0.001). Through receiver operating characteristic curve analyses, it was found that plasma melatonin could be used as a diagnostic biomarker for IDD (area under curve=0.808, P< 0.001). In advanced correlation analyses, it was found that plasma melatonin concentration was negatively associated with the age, symptom durations, IDD disease severity and proinflammatory factors, including IL-6 and TNF-α concentrations (P< 0.05). Comparing with the higher melatonin groups, significantly increased IL-6 (0.601 ± 0.085 vs 0.507 ± 0.167 pg/mL, P=0.028) and TNF-α (3.022 ± 0.286 vs 2.353 ± 0.641, P< 0.001) were detected in the patients with lower melatonin concentration.Conclusion: The plasma melatonin concentration was significantly decreased in the IDD cases and plasma melatonin could be used as a diagnostic biomarker for IDD. Lower plasma melatonin was associated with longer disease durations, elevated disease severity and higher inflammatory cytokines levels in IDD patients.Keywords: intervertebral disc degeneration, melatonin, biomarker, inflammatory factors
format	article
author	Tian Y Ji Y Mei X Pan J He W Sun J Wan K Yang H
author_facet	Tian Y Ji Y Mei X Pan J He W Sun J Wan K Yang H
author_sort	Tian Y
title	Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines
title_short	Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines
title_full	Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines
title_fullStr	Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines
title_full_unstemmed	Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines
title_sort	lower plasma melatonin in the intervertebral disk degeneration patients was associated with increased proinflammatory cytokines
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4bc32f1541c24c52807b297a9185d996
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Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines

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