Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars

Abstract Hypertrophic scars represent a common complication in burn patients. In addition to cosmetic defects, they may cause serious sensory abnormalities such as pain and itching, severe dysfunction depending on the site, and emotional disorders such as anxiety and depression. The present study ai...

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Autores principales:	Hui Song Cui, So Young Joo, Yoon Soo Cho, Ji Heon Park, Yu Mi Ro, June-Bum Kim, Cheong Hoon Seo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4bc488a1983c4d8e8f63ea186e4e1eb1
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spelling	oai:doaj.org-article:4bc488a1983c4d8e8f63ea186e4e1eb12021-12-02T16:34:54ZEffect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars10.1038/s41598-021-96537-82045-2322https://doaj.org/article/4bc488a1983c4d8e8f63ea186e4e1eb12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96537-8https://doaj.org/toc/2045-2322Abstract Hypertrophic scars represent a common complication in burn patients. In addition to cosmetic defects, they may cause serious sensory abnormalities such as pain and itching, severe dysfunction depending on the site, and emotional disorders such as anxiety and depression. The present study aimed to identify the molecular mechanisms underlying the use of extracorporeal shock wave therapy in keratinocytes. Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers (keratin 5 and 14), activation markers (keratin 6 and 17), differentiation markers (keratin 1, 10, and involucrin), apoptosis factors (Bax, Bcl2, and Caspase 14), and proliferation/differentiation regulators (p21 and p27) was investigated to compared with that of those in keratinocytes derived from normal skin tissue. Scar-derived keratinocytes were treated with extracorporeal shock waves under 1000 impulses at 0.1, 0.2, and 0.3 mJ/mm2. Shock waves altered the molecular pattern of proliferation, activation, differentiation, and apoptosis, as well as proliferation/ differentiation regulators, including Bax, Bcl2, ASK1, p21, p27, and Notch1. In summary, we show that extracorporeal shock wave therapy regulates the proliferation and differentiation of keratinocytes derived from hypertrophic scar to maintain normal epidermal integrity.Hui Song CuiSo Young JooYoon Soo ChoJi Heon ParkYu Mi RoJune-Bum KimCheong Hoon SeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui Song Cui So Young Joo Yoon Soo Cho Ji Heon Park Yu Mi Ro June-Bum Kim Cheong Hoon Seo Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars
description	Abstract Hypertrophic scars represent a common complication in burn patients. In addition to cosmetic defects, they may cause serious sensory abnormalities such as pain and itching, severe dysfunction depending on the site, and emotional disorders such as anxiety and depression. The present study aimed to identify the molecular mechanisms underlying the use of extracorporeal shock wave therapy in keratinocytes. Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers (keratin 5 and 14), activation markers (keratin 6 and 17), differentiation markers (keratin 1, 10, and involucrin), apoptosis factors (Bax, Bcl2, and Caspase 14), and proliferation/differentiation regulators (p21 and p27) was investigated to compared with that of those in keratinocytes derived from normal skin tissue. Scar-derived keratinocytes were treated with extracorporeal shock waves under 1000 impulses at 0.1, 0.2, and 0.3 mJ/mm2. Shock waves altered the molecular pattern of proliferation, activation, differentiation, and apoptosis, as well as proliferation/ differentiation regulators, including Bax, Bcl2, ASK1, p21, p27, and Notch1. In summary, we show that extracorporeal shock wave therapy regulates the proliferation and differentiation of keratinocytes derived from hypertrophic scar to maintain normal epidermal integrity.
format	article
author	Hui Song Cui So Young Joo Yoon Soo Cho Ji Heon Park Yu Mi Ro June-Bum Kim Cheong Hoon Seo
author_facet	Hui Song Cui So Young Joo Yoon Soo Cho Ji Heon Park Yu Mi Ro June-Bum Kim Cheong Hoon Seo
author_sort	Hui Song Cui
title	Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars
title_short	Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars
title_full	Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars
title_fullStr	Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars
title_full_unstemmed	Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars
title_sort	effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4bc488a1983c4d8e8f63ea186e4e1eb1
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Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars

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