PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)

The review presents and discusses modern conceptions about causes of development, existing ways of prevention and correction of liver failure. Unsatisfactory effectiveness of traditional infusion and medicinal therapy, as well as low availability of extracorporal detoxification and liver transplanta...

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Autores principales:	A. I. Iskra, S. A. Lepekhova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2014
Materias:	liver failure biotechnology cell transplantation Science Q
Acceso en línea:	https://doaj.org/article/4bc5083f48bb4eea8fedb5230b555e85
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id	oai:doaj.org-article:4bc5083f48bb4eea8fedb5230b555e85
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spelling	oai:doaj.org-article:4bc5083f48bb4eea8fedb5230b555e852021-11-23T06:14:29ZPROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)2541-94202587-9596https://doaj.org/article/4bc5083f48bb4eea8fedb5230b555e852014-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1724https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The review presents and discusses modern conceptions about causes of development, existing ways of prevention and correction of liver failure. Unsatisfactory effectiveness of traditional infusion and medicinal therapy, as well as low availability of extracorporal detoxification and liver transplantation methods generates a need for search of brand new patogeneticaly substantiated methods of treatment of liver failure. The data about pathogenesis of liver failure and about sanogenesis and regeneration processes are presented. Hepatocite growth factor plays leading role in that processes, most important effects of present cytokine are considered. Next part of the article describes principles, mechanism of action and results of experimental use of cell therapy method. This method has shown effectiveness in animal models and it is perspective for further improvement, but not allowed for clinical use. That's why authors consider that the most perspective solution is creation of new drug, containing regulatory peptides of liver.A. I. IskraS. A. LepekhovaScientific Сentre for Family Health and Human Reproduction Problemsarticleliver failurebiotechnologycell transplantationScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 112-119 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	liver failure biotechnology cell transplantation Science Q
spellingShingle	liver failure biotechnology cell transplantation Science Q A. I. Iskra S. A. Lepekhova PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)
description	The review presents and discusses modern conceptions about causes of development, existing ways of prevention and correction of liver failure. Unsatisfactory effectiveness of traditional infusion and medicinal therapy, as well as low availability of extracorporal detoxification and liver transplantation methods generates a need for search of brand new patogeneticaly substantiated methods of treatment of liver failure. The data about pathogenesis of liver failure and about sanogenesis and regeneration processes are presented. Hepatocite growth factor plays leading role in that processes, most important effects of present cytokine are considered. Next part of the article describes principles, mechanism of action and results of experimental use of cell therapy method. This method has shown effectiveness in animal models and it is perspective for further improvement, but not allowed for clinical use. That's why authors consider that the most perspective solution is creation of new drug, containing regulatory peptides of liver.
format	article
author	A. I. Iskra S. A. Lepekhova
author_facet	A. I. Iskra S. A. Lepekhova
author_sort	A. I. Iskra
title	PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)
title_short	PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)
title_full	PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)
title_fullStr	PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)
title_full_unstemmed	PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)
title_sort	prospect of using biotechnologies for correction of liver failure (review of literature)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2014
url	https://doaj.org/article/4bc5083f48bb4eea8fedb5230b555e85
work_keys_str_mv	AT aiiskra prospectofusingbiotechnologiesforcorrectionofliverfailurereviewofliterature AT salepekhova prospectofusingbiotechnologiesforcorrectionofliverfailurereviewofliterature
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PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)

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