Systematic detection of functional proteoform groups from bottom-up proteomic datasets

Many proteins exist in various proteoforms but detecting these variants by bottom-up proteomics remains difficult. Here, the authors present a computational approach based on peptide correlation analysis to identify and characterize proteoforms from bottom-up proteomics data.

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Autores principales:	Isabell Bludau, Max Frank, Christian Dörig, Yujia Cai, Moritz Heusel, George Rosenberger, Paola Picotti, Ben C. Collins, Hannes Röst, Ruedi Aebersold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bc622ef871944e7b4a94176e06f1144
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spelling	oai:doaj.org-article:4bc622ef871944e7b4a94176e06f11442021-12-02T16:05:50ZSystematic detection of functional proteoform groups from bottom-up proteomic datasets10.1038/s41467-021-24030-x2041-1723https://doaj.org/article/4bc622ef871944e7b4a94176e06f11442021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24030-xhttps://doaj.org/toc/2041-1723Many proteins exist in various proteoforms but detecting these variants by bottom-up proteomics remains difficult. Here, the authors present a computational approach based on peptide correlation analysis to identify and characterize proteoforms from bottom-up proteomics data.Isabell BludauMax FrankChristian DörigYujia CaiMoritz HeuselGeorge RosenbergerPaola PicottiBen C. CollinsHannes RöstRuedi AebersoldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabell Bludau Max Frank Christian Dörig Yujia Cai Moritz Heusel George Rosenberger Paola Picotti Ben C. Collins Hannes Röst Ruedi Aebersold Systematic detection of functional proteoform groups from bottom-up proteomic datasets
description	Many proteins exist in various proteoforms but detecting these variants by bottom-up proteomics remains difficult. Here, the authors present a computational approach based on peptide correlation analysis to identify and characterize proteoforms from bottom-up proteomics data.
format	article
author	Isabell Bludau Max Frank Christian Dörig Yujia Cai Moritz Heusel George Rosenberger Paola Picotti Ben C. Collins Hannes Röst Ruedi Aebersold
author_facet	Isabell Bludau Max Frank Christian Dörig Yujia Cai Moritz Heusel George Rosenberger Paola Picotti Ben C. Collins Hannes Röst Ruedi Aebersold
author_sort	Isabell Bludau
title	Systematic detection of functional proteoform groups from bottom-up proteomic datasets
title_short	Systematic detection of functional proteoform groups from bottom-up proteomic datasets
title_full	Systematic detection of functional proteoform groups from bottom-up proteomic datasets
title_fullStr	Systematic detection of functional proteoform groups from bottom-up proteomic datasets
title_full_unstemmed	Systematic detection of functional proteoform groups from bottom-up proteomic datasets
title_sort	systematic detection of functional proteoform groups from bottom-up proteomic datasets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4bc622ef871944e7b4a94176e06f1144
work_keys_str_mv	AT isabellbludau systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT maxfrank systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT christiandorig systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT yujiacai systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT moritzheusel systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT georgerosenberger systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT paolapicotti systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT benccollins systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT hannesrost systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets AT ruediaebersold systematicdetectionoffunctionalproteoformgroupsfrombottomupproteomicdatasets
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Systematic detection of functional proteoform groups from bottom-up proteomic datasets

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