Astrocytes gate Hebbian synaptic plasticity in the striatum

Astrocytes regulate synaptic signalling via EAAT glutamate uptake, though whether they play a role in Hebbian plasticity is unknown. Here, the authors find targeting EAAT2 disrupts the emergence of spike timing-dependent plasticity, which highlights the role of astrocytes as gatekeepers for Hebbian...

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Autores principales: Silvana Valtcheva, Laurent Venance
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4bcb008e329f4f02bc319373edc7a8d2
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Sumario:Astrocytes regulate synaptic signalling via EAAT glutamate uptake, though whether they play a role in Hebbian plasticity is unknown. Here, the authors find targeting EAAT2 disrupts the emergence of spike timing-dependent plasticity, which highlights the role of astrocytes as gatekeepers for Hebbian plasticity.