Astrocytes gate Hebbian synaptic plasticity in the striatum

Astrocytes regulate synaptic signalling via EAAT glutamate uptake, though whether they play a role in Hebbian plasticity is unknown. Here, the authors find targeting EAAT2 disrupts the emergence of spike timing-dependent plasticity, which highlights the role of astrocytes as gatekeepers for Hebbian...

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Autores principales:	Silvana Valtcheva, Laurent Venance
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bcb008e329f4f02bc319373edc7a8d2
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spelling	oai:doaj.org-article:4bcb008e329f4f02bc319373edc7a8d22021-12-02T14:40:12ZAstrocytes gate Hebbian synaptic plasticity in the striatum10.1038/ncomms138452041-1723https://doaj.org/article/4bcb008e329f4f02bc319373edc7a8d22016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13845https://doaj.org/toc/2041-1723Astrocytes regulate synaptic signalling via EAAT glutamate uptake, though whether they play a role in Hebbian plasticity is unknown. Here, the authors find targeting EAAT2 disrupts the emergence of spike timing-dependent plasticity, which highlights the role of astrocytes as gatekeepers for Hebbian plasticity.Silvana ValtchevaLaurent VenanceNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvana Valtcheva Laurent Venance Astrocytes gate Hebbian synaptic plasticity in the striatum
description	Astrocytes regulate synaptic signalling via EAAT glutamate uptake, though whether they play a role in Hebbian plasticity is unknown. Here, the authors find targeting EAAT2 disrupts the emergence of spike timing-dependent plasticity, which highlights the role of astrocytes as gatekeepers for Hebbian plasticity.
format	article
author	Silvana Valtcheva Laurent Venance
author_facet	Silvana Valtcheva Laurent Venance
author_sort	Silvana Valtcheva
title	Astrocytes gate Hebbian synaptic plasticity in the striatum
title_short	Astrocytes gate Hebbian synaptic plasticity in the striatum
title_full	Astrocytes gate Hebbian synaptic plasticity in the striatum
title_fullStr	Astrocytes gate Hebbian synaptic plasticity in the striatum
title_full_unstemmed	Astrocytes gate Hebbian synaptic plasticity in the striatum
title_sort	astrocytes gate hebbian synaptic plasticity in the striatum
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4bcb008e329f4f02bc319373edc7a8d2
work_keys_str_mv	AT silvanavaltcheva astrocytesgatehebbiansynapticplasticityinthestriatum AT laurentvenance astrocytesgatehebbiansynapticplasticityinthestriatum
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Astrocytes gate Hebbian synaptic plasticity in the striatum

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