Long-term cardiovascular complications following sepsis: is senescence the missing link?

Highlights With improved management of patients, sepsis survivors are increasing each year. Early cardiovascular complications, of yet undeciphered mechanisms, are an emerging health issue in post-sepsis syndrome. Premature senescence of endothelium and vascular tissue is proven an accelerated proce...

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Autores principales:	Hamid Merdji, Valérie Schini-Kerth, Ferhat Meziani, Florence Toti
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Septic shock Sepsis Stress-induced premature senescence (SIPS) Atherosclerosis Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/4bcd5acaf9934d0e824ae36458aefcd1
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spelling	oai:doaj.org-article:4bcd5acaf9934d0e824ae36458aefcd12021-12-05T12:03:46ZLong-term cardiovascular complications following sepsis: is senescence the missing link?10.1186/s13613-021-00937-y2110-5820https://doaj.org/article/4bcd5acaf9934d0e824ae36458aefcd12021-12-01T00:00:00Zhttps://doi.org/10.1186/s13613-021-00937-yhttps://doaj.org/toc/2110-5820Highlights With improved management of patients, sepsis survivors are increasing each year. Early cardiovascular complications, of yet undeciphered mechanisms, are an emerging health issue in post-sepsis syndrome. Premature senescence of endothelium and vascular tissue is proven an accelerated process of atherogenesis in young septic rats. An increasing body of clinical evidence point at endothelial senescence in the initiation and development of atherosclerosis. Prevention of premature senescence by senotherapy and cardiological follow-up could improve long-term septic patients’ outcomes.Hamid MerdjiValérie Schini-KerthFerhat MezianiFlorence TotiSpringerOpenarticleSeptic shockSepsisStress-induced premature senescence (SIPS)AtherosclerosisMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENAnnals of Intensive Care, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Septic shock Sepsis Stress-induced premature senescence (SIPS) Atherosclerosis Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	Septic shock Sepsis Stress-induced premature senescence (SIPS) Atherosclerosis Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Hamid Merdji Valérie Schini-Kerth Ferhat Meziani Florence Toti Long-term cardiovascular complications following sepsis: is senescence the missing link?
description	Highlights With improved management of patients, sepsis survivors are increasing each year. Early cardiovascular complications, of yet undeciphered mechanisms, are an emerging health issue in post-sepsis syndrome. Premature senescence of endothelium and vascular tissue is proven an accelerated process of atherogenesis in young septic rats. An increasing body of clinical evidence point at endothelial senescence in the initiation and development of atherosclerosis. Prevention of premature senescence by senotherapy and cardiological follow-up could improve long-term septic patients’ outcomes.
format	article
author	Hamid Merdji Valérie Schini-Kerth Ferhat Meziani Florence Toti
author_facet	Hamid Merdji Valérie Schini-Kerth Ferhat Meziani Florence Toti
author_sort	Hamid Merdji
title	Long-term cardiovascular complications following sepsis: is senescence the missing link?
title_short	Long-term cardiovascular complications following sepsis: is senescence the missing link?
title_full	Long-term cardiovascular complications following sepsis: is senescence the missing link?
title_fullStr	Long-term cardiovascular complications following sepsis: is senescence the missing link?
title_full_unstemmed	Long-term cardiovascular complications following sepsis: is senescence the missing link?
title_sort	long-term cardiovascular complications following sepsis: is senescence the missing link?
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/4bcd5acaf9934d0e824ae36458aefcd1
work_keys_str_mv	AT hamidmerdji longtermcardiovascularcomplicationsfollowingsepsisissenescencethemissinglink AT valerieschinikerth longtermcardiovascularcomplicationsfollowingsepsisissenescencethemissinglink AT ferhatmeziani longtermcardiovascularcomplicationsfollowingsepsisissenescencethemissinglink AT florencetoti longtermcardiovascularcomplicationsfollowingsepsisissenescencethemissinglink
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Long-term cardiovascular complications following sepsis: is senescence the missing link?

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