CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to explore pore-formation in molecular detail.

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Autores principales:	Anaïs Menny, Marina Serna, Courtney M. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bd0eaed6b53416380fc69476cf0e63b
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spelling	oai:doaj.org-article:4bd0eaed6b53416380fc69476cf0e63b2021-12-02T14:39:25ZCryoEM reveals how the complement membrane attack complex ruptures lipid bilayers10.1038/s41467-018-07653-52041-1723https://doaj.org/article/4bd0eaed6b53416380fc69476cf0e63b2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07653-5https://doaj.org/toc/2041-1723The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to explore pore-formation in molecular detail.Anaïs MennyMarina SernaCourtney M. BoydScott GardnerAgnel Praveen JosephB. Paul MorganMaya TopfNicholas J. BrooksDoryen BubeckNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anaïs Menny Marina Serna Courtney M. Boyd Scott Gardner Agnel Praveen Joseph B. Paul Morgan Maya Topf Nicholas J. Brooks Doryen Bubeck CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
description	The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to explore pore-formation in molecular detail.
format	article
author	Anaïs Menny Marina Serna Courtney M. Boyd Scott Gardner Agnel Praveen Joseph B. Paul Morgan Maya Topf Nicholas J. Brooks Doryen Bubeck
author_facet	Anaïs Menny Marina Serna Courtney M. Boyd Scott Gardner Agnel Praveen Joseph B. Paul Morgan Maya Topf Nicholas J. Brooks Doryen Bubeck
author_sort	Anaïs Menny
title	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
title_short	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
title_full	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
title_fullStr	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
title_full_unstemmed	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
title_sort	cryoem reveals how the complement membrane attack complex ruptures lipid bilayers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4bd0eaed6b53416380fc69476cf0e63b
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CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

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