STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 inf...
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Nature Portfolio
2020
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oai:doaj.org-article:4bd55434a94243038b030da67ad476bb2021-12-02T15:39:13ZSTAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters10.1038/s41467-020-19684-y2041-1723https://doaj.org/article/4bd55434a94243038b030da67ad476bb2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19684-yhttps://doaj.org/toc/2041-1723SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection.Robbert BoudewijnsHendrik Jan ThibautSuzanne J. F. KapteinRong LiValentijn VergoteLaura SeldeslachtsJohan Van WeyenberghCarolien De KeyzerLindsey BervoetsSapna SharmaLaurens LiesenborghsJi MaSander JansenDominique Van LooverenThomas VercruysseXinyu WangDirk JochmansErik MartensKenny RooseDorien De VliegerBert SchepensTina Van BuytenSofie JacobsYanan LiuJoan Martí-CarrerasBert VanmechelenTony Wawina-BokalangaLeen DelangJoana Rocha-PereiraLotte CoelmontWinston ChiuPieter LeyssenElisabeth HeylenDominique ScholsLanjiao WangLila CloseJelle MatthijnssensMarc Van RanstVeerle CompernolleGeorg SchrammKoen Van LaereXavier SaelensNico CallewaertGhislain OpdenakkerPiet MaesBirgit WeynandChristopher CawthorneGreetje Vande VeldeZhongde WangJohan NeytsKai DallmeierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Robbert Boudewijns Hendrik Jan Thibaut Suzanne J. F. Kaptein Rong Li Valentijn Vergote Laura Seldeslachts Johan Van Weyenbergh Carolien De Keyzer Lindsey Bervoets Sapna Sharma Laurens Liesenborghs Ji Ma Sander Jansen Dominique Van Looveren Thomas Vercruysse Xinyu Wang Dirk Jochmans Erik Martens Kenny Roose Dorien De Vlieger Bert Schepens Tina Van Buyten Sofie Jacobs Yanan Liu Joan Martí-Carreras Bert Vanmechelen Tony Wawina-Bokalanga Leen Delang Joana Rocha-Pereira Lotte Coelmont Winston Chiu Pieter Leyssen Elisabeth Heylen Dominique Schols Lanjiao Wang Lila Close Jelle Matthijnssens Marc Van Ranst Veerle Compernolle Georg Schramm Koen Van Laere Xavier Saelens Nico Callewaert Ghislain Opdenakker Piet Maes Birgit Weynand Christopher Cawthorne Greetje Vande Velde Zhongde Wang Johan Neyts Kai Dallmeier STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters |
| description |
SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection. |
| format |
article |
| author |
Robbert Boudewijns Hendrik Jan Thibaut Suzanne J. F. Kaptein Rong Li Valentijn Vergote Laura Seldeslachts Johan Van Weyenbergh Carolien De Keyzer Lindsey Bervoets Sapna Sharma Laurens Liesenborghs Ji Ma Sander Jansen Dominique Van Looveren Thomas Vercruysse Xinyu Wang Dirk Jochmans Erik Martens Kenny Roose Dorien De Vlieger Bert Schepens Tina Van Buyten Sofie Jacobs Yanan Liu Joan Martí-Carreras Bert Vanmechelen Tony Wawina-Bokalanga Leen Delang Joana Rocha-Pereira Lotte Coelmont Winston Chiu Pieter Leyssen Elisabeth Heylen Dominique Schols Lanjiao Wang Lila Close Jelle Matthijnssens Marc Van Ranst Veerle Compernolle Georg Schramm Koen Van Laere Xavier Saelens Nico Callewaert Ghislain Opdenakker Piet Maes Birgit Weynand Christopher Cawthorne Greetje Vande Velde Zhongde Wang Johan Neyts Kai Dallmeier |
| author_facet |
Robbert Boudewijns Hendrik Jan Thibaut Suzanne J. F. Kaptein Rong Li Valentijn Vergote Laura Seldeslachts Johan Van Weyenbergh Carolien De Keyzer Lindsey Bervoets Sapna Sharma Laurens Liesenborghs Ji Ma Sander Jansen Dominique Van Looveren Thomas Vercruysse Xinyu Wang Dirk Jochmans Erik Martens Kenny Roose Dorien De Vlieger Bert Schepens Tina Van Buyten Sofie Jacobs Yanan Liu Joan Martí-Carreras Bert Vanmechelen Tony Wawina-Bokalanga Leen Delang Joana Rocha-Pereira Lotte Coelmont Winston Chiu Pieter Leyssen Elisabeth Heylen Dominique Schols Lanjiao Wang Lila Close Jelle Matthijnssens Marc Van Ranst Veerle Compernolle Georg Schramm Koen Van Laere Xavier Saelens Nico Callewaert Ghislain Opdenakker Piet Maes Birgit Weynand Christopher Cawthorne Greetje Vande Velde Zhongde Wang Johan Neyts Kai Dallmeier |
| author_sort |
Robbert Boudewijns |
| title |
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters |
| title_short |
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters |
| title_full |
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters |
| title_fullStr |
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters |
| title_full_unstemmed |
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters |
| title_sort |
stat2 signaling restricts viral dissemination but drives severe pneumonia in sars-cov-2 infected hamsters |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4bd55434a94243038b030da67ad476bb |
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