Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.

<h4>Background</h4>Successful reduction of body weight (BW) is often followed by recidivism to obesity. BW-changes including BW-loss and -regain is associated with marked alterations in energy expenditure (EE) and adipose tissue (AT) metabolism. Since these processes are sex-specifically...

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Autores principales:	Verena Benz, Mandy Bloch, Sami Wardat, Christian Böhm, Lukas Maurer, Shokoufeh Mahmoodzadeh, Petra Wiedmer, Joachim Spranger, Anna Foryst-Ludwig, Ulrich Kintscher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4bd784ca14c843f2929257bf0bfa0ebd
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spelling	oai:doaj.org-article:4bd784ca14c843f2929257bf0bfa0ebd2021-11-18T07:17:16ZSexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.1932-620310.1371/journal.pone.0037794https://doaj.org/article/4bd784ca14c843f2929257bf0bfa0ebd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22662224/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Successful reduction of body weight (BW) is often followed by recidivism to obesity. BW-changes including BW-loss and -regain is associated with marked alterations in energy expenditure (EE) and adipose tissue (AT) metabolism. Since these processes are sex-specifically controlled, we investigated sexual dimorphisms in metabolic processes during BW-dynamics (gain-loss-regain).<h4>Research design</h4>Obesity was induced in C57BL/6J male (m) and female (f) mice by 15 weeks high-fat diet (HFD) feeding. Subsequently BW was reduced (-20%) by caloric restriction (CR) followed by adaptive feeding, and a regain-phase. Measurement of EE, body composition, blood/organ sampling were performed after each feeding period. Lipolysis was analyzed ex-vivo in gonadal AT.<h4>Results</h4>Male mice exhibited accelerated BW-gain compared to females (relative BW-gain m:140.5±3.2%; f:103.7±6.5%; p<0.001). In consonance, lean mass-specific EE was significantly higher in females compared to males during BW-gain. Under CR female mice reached their target-BW significantly faster than male mice (m:12.2 days; f:7.6 days; p<0.001) accompanied by a sustained sex-difference in EE. In addition, female mice predominantly downsized gonadal AT whereas the relation between gonadal and total body fat was not altered in males. Accordingly, only females exhibited an increased rate of forskolin-stimulated lipolysis in AT associated with significantly higher glycerol concentrations, lower RER-values, and increased AT expression of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL). Analysis of AT lipolysis in estrogen receptor alpha (ERα)-deficient mice revealed a reduced lipolytic rate in the absence of ERα exclusively in females. Finally, re-feeding caused BW-regain faster in males than in females.<h4>Conclusion</h4>The present study shows sex-specific dynamics during BW-gain-loss-regain. Female mice responded to CR with an increase in lipolytic activity, and augmented lipid-oxidation leading to more efficient weight loss. These processes likely involve ERα-dependent signaling in AT and sexual dimorphic regulation of genes involved in lipid metabolism.Verena BenzMandy BlochSami WardatChristian BöhmLukas MaurerShokoufeh MahmoodzadehPetra WiedmerJoachim SprangerAnna Foryst-LudwigUlrich KintscherPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37794 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Verena Benz Mandy Bloch Sami Wardat Christian Böhm Lukas Maurer Shokoufeh Mahmoodzadeh Petra Wiedmer Joachim Spranger Anna Foryst-Ludwig Ulrich Kintscher Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
description	<h4>Background</h4>Successful reduction of body weight (BW) is often followed by recidivism to obesity. BW-changes including BW-loss and -regain is associated with marked alterations in energy expenditure (EE) and adipose tissue (AT) metabolism. Since these processes are sex-specifically controlled, we investigated sexual dimorphisms in metabolic processes during BW-dynamics (gain-loss-regain).<h4>Research design</h4>Obesity was induced in C57BL/6J male (m) and female (f) mice by 15 weeks high-fat diet (HFD) feeding. Subsequently BW was reduced (-20%) by caloric restriction (CR) followed by adaptive feeding, and a regain-phase. Measurement of EE, body composition, blood/organ sampling were performed after each feeding period. Lipolysis was analyzed ex-vivo in gonadal AT.<h4>Results</h4>Male mice exhibited accelerated BW-gain compared to females (relative BW-gain m:140.5±3.2%; f:103.7±6.5%; p<0.001). In consonance, lean mass-specific EE was significantly higher in females compared to males during BW-gain. Under CR female mice reached their target-BW significantly faster than male mice (m:12.2 days; f:7.6 days; p<0.001) accompanied by a sustained sex-difference in EE. In addition, female mice predominantly downsized gonadal AT whereas the relation between gonadal and total body fat was not altered in males. Accordingly, only females exhibited an increased rate of forskolin-stimulated lipolysis in AT associated with significantly higher glycerol concentrations, lower RER-values, and increased AT expression of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL). Analysis of AT lipolysis in estrogen receptor alpha (ERα)-deficient mice revealed a reduced lipolytic rate in the absence of ERα exclusively in females. Finally, re-feeding caused BW-regain faster in males than in females.<h4>Conclusion</h4>The present study shows sex-specific dynamics during BW-gain-loss-regain. Female mice responded to CR with an increase in lipolytic activity, and augmented lipid-oxidation leading to more efficient weight loss. These processes likely involve ERα-dependent signaling in AT and sexual dimorphic regulation of genes involved in lipid metabolism.
format	article
author	Verena Benz Mandy Bloch Sami Wardat Christian Böhm Lukas Maurer Shokoufeh Mahmoodzadeh Petra Wiedmer Joachim Spranger Anna Foryst-Ludwig Ulrich Kintscher
author_facet	Verena Benz Mandy Bloch Sami Wardat Christian Böhm Lukas Maurer Shokoufeh Mahmoodzadeh Petra Wiedmer Joachim Spranger Anna Foryst-Ludwig Ulrich Kintscher
author_sort	Verena Benz
title	Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
title_short	Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
title_full	Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
title_fullStr	Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
title_full_unstemmed	Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
title_sort	sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4bd784ca14c843f2929257bf0bfa0ebd
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Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis.

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