Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet h...

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Autores principales: Claire B. Péan, Mark Schiebler, Sharon W. S. Tan, Jessica A. Sharrock, Katrin Kierdorf, Karen P. Brown, M. Charlotte Maserumule, Shinelle Menezes, Martina Pilátová, Kévin Bronda, Pierre Guermonprez, Brian M. Stramer, R. Andres Floto, Marc S. Dionne
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4bd8daccf57b461585b4d2bad37cf1c1
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Sumario:Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis.

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