Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet h...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Claire B. Péan, Mark Schiebler, Sharon W. S. Tan, Jessica A. Sharrock, Katrin Kierdorf, Karen P. Brown, M. Charlotte Maserumule, Shinelle Menezes, Martina Pilátová, Kévin Bronda, Pierre Guermonprez, Brian M. Stramer, R. Andres Floto, Marc S. Dionne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bd8daccf57b461585b4d2bad37cf1c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4bd8daccf57b461585b4d2bad37cf1c1
record_format	dspace
spelling	oai:doaj.org-article:4bd8daccf57b461585b4d2bad37cf1c12021-12-02T14:41:18ZRegulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection10.1038/ncomms146422041-1723https://doaj.org/article/4bd8daccf57b461585b4d2bad37cf1c12017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14642https://doaj.org/toc/2041-1723Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis.Claire B. PéanMark SchieblerSharon W. S. TanJessica A. SharrockKatrin KierdorfKaren P. BrownM. Charlotte MaserumuleShinelle MenezesMartina PilátováKévin BrondaPierre GuermonprezBrian M. StramerR. Andres FlotoMarc S. DionneNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claire B. Péan Mark Schiebler Sharon W. S. Tan Jessica A. Sharrock Katrin Kierdorf Karen P. Brown M. Charlotte Maserumule Shinelle Menezes Martina Pilátová Kévin Bronda Pierre Guermonprez Brian M. Stramer R. Andres Floto Marc S. Dionne Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
description	Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis.
format	article
author	Claire B. Péan Mark Schiebler Sharon W. S. Tan Jessica A. Sharrock Katrin Kierdorf Karen P. Brown M. Charlotte Maserumule Shinelle Menezes Martina Pilátová Kévin Bronda Pierre Guermonprez Brian M. Stramer R. Andres Floto Marc S. Dionne
author_facet	Claire B. Péan Mark Schiebler Sharon W. S. Tan Jessica A. Sharrock Katrin Kierdorf Karen P. Brown M. Charlotte Maserumule Shinelle Menezes Martina Pilátová Kévin Bronda Pierre Guermonprez Brian M. Stramer R. Andres Floto Marc S. Dionne
author_sort	Claire B. Péan
title	Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
title_short	Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
title_full	Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
title_fullStr	Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
title_full_unstemmed	Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
title_sort	regulation of phagocyte triglyceride by a stat-atg2 pathway controls mycobacterial infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4bd8daccf57b461585b4d2bad37cf1c1
work_keys_str_mv	AT clairebpean regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT markschiebler regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT sharonwstan regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT jessicaasharrock regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT katrinkierdorf regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT karenpbrown regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT mcharlottemaserumule regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT shinellemenezes regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT martinapilatova regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT kevinbronda regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT pierreguermonprez regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT brianmstramer regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT randresfloto regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection AT marcsdionne regulationofphagocytetriglyceridebyastatatg2pathwaycontrolsmycobacterialinfection
_version_	1718389928597913600

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

Ejemplares similares