Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)

Background. Due to the growing light pollution and the development of new territories, including northern ones, the search for drugs that increase the adaptive capacity of the organism is promising.The aim. We studied the effects of the exogenous melatonin (100 µg/day/animal) on antioxidant status o...

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Autores principales:	E. P. Antonova, A. D. Volodina, V. A. Ilyukha
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	light mode melatonin antioxidant system liver small intestine Science Q
Acceso en línea:	https://doaj.org/article/4bd95baaace94dc583b9934424a8c01b
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spelling	oai:doaj.org-article:4bd95baaace94dc583b9934424a8c01b2021-11-23T06:14:46ZEffect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)2541-94202587-959610.29413/ABS.2021-6.4.24https://doaj.org/article/4bd95baaace94dc583b9934424a8c01b2021-10-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2998https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Due to the growing light pollution and the development of new territories, including northern ones, the search for drugs that increase the adaptive capacity of the organism is promising.The aim. We studied the effects of the exogenous melatonin (100 µg/day/animal) on antioxidant status of liver and small intestine in Syrian hamsters (Mesocricetus auratus) in the light conditions of North-West of Russia (Petrozavodsk, northern lighting – NL).Materials and methods. Female hamsters were exposed to a 12/12 light/dark cycle (LD; n = 12) or NL for 3 months. In NL light conditions hamsters were divided into two groups: NL-control (received placebo; n = 12) and NL-mel (received melatonin; n = 12). The study was conducted from the period of the summer solstice – June 25 (NL: 19.36/4.24) to September 25 (NL: 12/12) (autumn equinox).Results. Animals were kept in the NL conditions had decreased the levels of GSH and activities of antioxidant enzymes (superoxide dismutase (SOD) and catalase) at initial stage of experiment as well as increased TBA reactive substances (TBARS) level at the beginning and after a month of the experiment in the liver in comparison to control (LD). It was observed that in the small intestine the activities of SOD and the levels of GSH (initial and intermediate stages) and TBARS (end of the experiment) were significantly higher in NL in comparison to LD. Liver and small intestine TBARS concentrations after one and three months of the experiment were decreased in NL-mel in comparison to NL-control.Conclusion. The results of the study indicate the sensitivity of the antioxidant defense system in the tissues of the liver and small intestine of Syrian hamster to the photoperiod and exogenous melatonin. The present study revealed that exogenous melatonin was able to reduce the level of TBARS and increase the activity of SOD and CAT in the light conditions of North-West of Russia.E. P. AntonovaA. D. VolodinaV. A. IlyukhaScientific Сentre for Family Health and Human Reproduction Problemsarticlelight modemelatoninantioxidant systemliversmall intestineScienceQRUActa Biomedica Scientifica, Vol 6, Iss 4, Pp 265-272 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	light mode melatonin antioxidant system liver small intestine Science Q
spellingShingle	light mode melatonin antioxidant system liver small intestine Science Q E. P. Antonova A. D. Volodina V. A. Ilyukha Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)
description	Background. Due to the growing light pollution and the development of new territories, including northern ones, the search for drugs that increase the adaptive capacity of the organism is promising.The aim. We studied the effects of the exogenous melatonin (100 µg/day/animal) on antioxidant status of liver and small intestine in Syrian hamsters (Mesocricetus auratus) in the light conditions of North-West of Russia (Petrozavodsk, northern lighting – NL).Materials and methods. Female hamsters were exposed to a 12/12 light/dark cycle (LD; n = 12) or NL for 3 months. In NL light conditions hamsters were divided into two groups: NL-control (received placebo; n = 12) and NL-mel (received melatonin; n = 12). The study was conducted from the period of the summer solstice – June 25 (NL: 19.36/4.24) to September 25 (NL: 12/12) (autumn equinox).Results. Animals were kept in the NL conditions had decreased the levels of GSH and activities of antioxidant enzymes (superoxide dismutase (SOD) and catalase) at initial stage of experiment as well as increased TBA reactive substances (TBARS) level at the beginning and after a month of the experiment in the liver in comparison to control (LD). It was observed that in the small intestine the activities of SOD and the levels of GSH (initial and intermediate stages) and TBARS (end of the experiment) were significantly higher in NL in comparison to LD. Liver and small intestine TBARS concentrations after one and three months of the experiment were decreased in NL-mel in comparison to NL-control.Conclusion. The results of the study indicate the sensitivity of the antioxidant defense system in the tissues of the liver and small intestine of Syrian hamster to the photoperiod and exogenous melatonin. The present study revealed that exogenous melatonin was able to reduce the level of TBARS and increase the activity of SOD and CAT in the light conditions of North-West of Russia.
format	article
author	E. P. Antonova A. D. Volodina V. A. Ilyukha
author_facet	E. P. Antonova A. D. Volodina V. A. Ilyukha
author_sort	E. P. Antonova
title	Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)
title_short	Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)
title_full	Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)
title_fullStr	Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)
title_full_unstemmed	Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)
title_sort	effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the syrian hamster (mesocricetus auratus)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/4bd95baaace94dc583b9934424a8c01b
work_keys_str_mv	AT epantonova effectofexogenousmelatoninontheantioxidantdefensesystemintheliverandsmallintestineofthesyrianhamstermesocricetusauratus AT advolodina effectofexogenousmelatoninontheantioxidantdefensesystemintheliverandsmallintestineofthesyrianhamstermesocricetusauratus AT vailyukha effectofexogenousmelatoninontheantioxidantdefensesystemintheliverandsmallintestineofthesyrianhamstermesocricetusauratus
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Effect of exogenous melatonin on the antioxidant defense system in the liver and small intestine of the Syrian hamster (Mesocricetus auratus)

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