Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities.

Guardado en:
Detalles Bibliográficos
Autores principales: Jianan Li, Wenxia Yu, Shisheng Huang, Susu Wu, Liping Li, Jiankui Zhou, Yu Cao, Xingxu Huang, Yunbo Qiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4bd9786b378c4e9cb51a4b505bd69951
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:4bd9786b378c4e9cb51a4b505bd69951
record_format dspace
spelling oai:doaj.org-article:4bd9786b378c4e9cb51a4b505bd699512021-12-02T15:51:07ZStructure-guided engineering of adenine base editor with minimized RNA off-targeting activity10.1038/s41467-021-22519-z2041-1723https://doaj.org/article/4bd9786b378c4e9cb51a4b505bd699512021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22519-zhttps://doaj.org/toc/2041-1723Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities.Jianan LiWenxia YuShisheng HuangSusu WuLiping LiJiankui ZhouYu CaoXingxu HuangYunbo QiaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jianan Li
Wenxia Yu
Shisheng Huang
Susu Wu
Liping Li
Jiankui Zhou
Yu Cao
Xingxu Huang
Yunbo Qiao
Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
description Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities.
format article
author Jianan Li
Wenxia Yu
Shisheng Huang
Susu Wu
Liping Li
Jiankui Zhou
Yu Cao
Xingxu Huang
Yunbo Qiao
author_facet Jianan Li
Wenxia Yu
Shisheng Huang
Susu Wu
Liping Li
Jiankui Zhou
Yu Cao
Xingxu Huang
Yunbo Qiao
author_sort Jianan Li
title Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
title_short Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
title_full Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
title_fullStr Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
title_full_unstemmed Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
title_sort structure-guided engineering of adenine base editor with minimized rna off-targeting activity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4bd9786b378c4e9cb51a4b505bd69951
work_keys_str_mv AT jiananli structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT wenxiayu structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT shishenghuang structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT susuwu structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT lipingli structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT jiankuizhou structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT yucao structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT xingxuhuang structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
AT yunboqiao structureguidedengineeringofadeninebaseeditorwithminimizedrnaofftargetingactivity
_version_ 1718385630998691840

Ejemplares similares