A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.

<h4>Background</h4>Within the cilia of vertebrate olfactory receptor neurons, Ca(2+) accumulates during odor transduction. Termination of the odor response requires removal of this Ca(2+), and prior evidence suggests that both Na(+)/Ca(2+) exchange and plasma membrane Ca(2+)-ATPase (PMCA...

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Autores principales:	Edwin R Griff, Nancy K Kleene, Steven J Kleene
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4bda36f7f30143dd8c91fba8ee1632dd
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spelling	oai:doaj.org-article:4bda36f7f30143dd8c91fba8ee1632dd2021-11-18T07:18:37ZA selective PMCA inhibitor does not prolong the electroolfactogram in mouse.1932-620310.1371/journal.pone.0037148https://doaj.org/article/4bda36f7f30143dd8c91fba8ee1632dd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22615924/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Within the cilia of vertebrate olfactory receptor neurons, Ca(2+) accumulates during odor transduction. Termination of the odor response requires removal of this Ca(2+), and prior evidence suggests that both Na(+)/Ca(2+) exchange and plasma membrane Ca(2+)-ATPase (PMCA) contribute to this removal.<h4>Principal findings</h4>In intact mouse olfactory epithelium, we measured the time course of termination of the odor-induced field potential. Replacement of mucosal Na(+) with Li(+), which reduces the ability of Na(+)/Ca(2+) exchange to expel Ca(2+), prolonged the termination as expected. However, treating the epithelium with the specific PMCA inhibitor caloxin 1b1 caused no significant increase in the time course of response termination.<h4>Conclusions</h4>Under these experimental conditions, PMCA does not contribute detectably to the termination of the odor response.Edwin R GriffNancy K KleeneSteven J KleenePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37148 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Edwin R Griff Nancy K Kleene Steven J Kleene A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.
description	<h4>Background</h4>Within the cilia of vertebrate olfactory receptor neurons, Ca(2+) accumulates during odor transduction. Termination of the odor response requires removal of this Ca(2+), and prior evidence suggests that both Na(+)/Ca(2+) exchange and plasma membrane Ca(2+)-ATPase (PMCA) contribute to this removal.<h4>Principal findings</h4>In intact mouse olfactory epithelium, we measured the time course of termination of the odor-induced field potential. Replacement of mucosal Na(+) with Li(+), which reduces the ability of Na(+)/Ca(2+) exchange to expel Ca(2+), prolonged the termination as expected. However, treating the epithelium with the specific PMCA inhibitor caloxin 1b1 caused no significant increase in the time course of response termination.<h4>Conclusions</h4>Under these experimental conditions, PMCA does not contribute detectably to the termination of the odor response.
format	article
author	Edwin R Griff Nancy K Kleene Steven J Kleene
author_facet	Edwin R Griff Nancy K Kleene Steven J Kleene
author_sort	Edwin R Griff
title	A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.
title_short	A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.
title_full	A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.
title_fullStr	A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.
title_full_unstemmed	A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.
title_sort	selective pmca inhibitor does not prolong the electroolfactogram in mouse.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4bda36f7f30143dd8c91fba8ee1632dd
work_keys_str_mv	AT edwinrgriff aselectivepmcainhibitordoesnotprolongtheelectroolfactograminmouse AT nancykkleene aselectivepmcainhibitordoesnotprolongtheelectroolfactograminmouse AT stevenjkleene aselectivepmcainhibitordoesnotprolongtheelectroolfactograminmouse AT edwinrgriff selectivepmcainhibitordoesnotprolongtheelectroolfactograminmouse AT nancykkleene selectivepmcainhibitordoesnotprolongtheelectroolfactograminmouse AT stevenjkleene selectivepmcainhibitordoesnotprolongtheelectroolfactograminmouse
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A selective PMCA inhibitor does not prolong the electroolfactogram in mouse.

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