SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation

T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt. Here the authors identify a new enhancer for RORγt, RORCE2, which synergizes with another TF, Sox5, for binding with RORγt...

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Autores principales:	Yi Tian, Chao Han, Zhiyuan Wei, Hui Dong, Xiaohe Shen, Yiqiang Cui, Xiaolan Fu, Zhiqiang Tian, Shufeng Wang, Jian Zhou, Di Yang, Yi Sun, Jizhao Yuan, Bing Ni, Yuzhang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bda70b629c6463d811f40ab5ed689ce
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spelling	oai:doaj.org-article:4bda70b629c6463d811f40ab5ed689ce2021-12-02T14:19:11ZSOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation10.1038/s41467-020-20786-w2041-1723https://doaj.org/article/4bda70b629c6463d811f40ab5ed689ce2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20786-whttps://doaj.org/toc/2041-1723T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt. Here the authors identify a new enhancer for RORγt, RORCE2, which synergizes with another TF, Sox5, for binding with RORγt promoter and thereby modulation of RORγt expression.Yi TianChao HanZhiyuan WeiHui DongXiaohe ShenYiqiang CuiXiaolan FuZhiqiang TianShufeng WangJian ZhouDi YangYi SunJizhao YuanBing NiYuzhang WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Tian Chao Han Zhiyuan Wei Hui Dong Xiaohe Shen Yiqiang Cui Xiaolan Fu Zhiqiang Tian Shufeng Wang Jian Zhou Di Yang Yi Sun Jizhao Yuan Bing Ni Yuzhang Wu SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
description	T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt. Here the authors identify a new enhancer for RORγt, RORCE2, which synergizes with another TF, Sox5, for binding with RORγt promoter and thereby modulation of RORγt expression.
format	article
author	Yi Tian Chao Han Zhiyuan Wei Hui Dong Xiaohe Shen Yiqiang Cui Xiaolan Fu Zhiqiang Tian Shufeng Wang Jian Zhou Di Yang Yi Sun Jizhao Yuan Bing Ni Yuzhang Wu
author_facet	Yi Tian Chao Han Zhiyuan Wei Hui Dong Xiaohe Shen Yiqiang Cui Xiaolan Fu Zhiqiang Tian Shufeng Wang Jian Zhou Di Yang Yi Sun Jizhao Yuan Bing Ni Yuzhang Wu
author_sort	Yi Tian
title	SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
title_short	SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
title_full	SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
title_fullStr	SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
title_full_unstemmed	SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
title_sort	sox-5 activates a novel rorγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting th17 cell differentiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4bda70b629c6463d811f40ab5ed689ce
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SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation

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