Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution

Recent studies suggest spatial segregation of tumor initiation and manifestation in IDH-WT glioblastomas. Here, the authors use serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree building to establish this unique evolutionary mode in a...

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Autores principales:	Yinghua Li, Bo Li, Wei Li, Yuan Wang, Seçkin Akgül, Daniel M. Treisman, Kevin A. Heist, Brianna R. Pierce, Benjamin Hoff, Cheng-Ying Ho, David O. Ferguson, Alnawaz Rehemtulla, Siyuan Zheng, Brian D. Ross, Jun Z. Li, Yuan Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bdb60bfd8b842efb554542d31c8e854
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spelling	oai:doaj.org-article:4bdb60bfd8b842efb554542d31c8e8542021-12-02T16:18:02ZMurine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution10.1038/s41467-020-17382-32041-1723https://doaj.org/article/4bdb60bfd8b842efb554542d31c8e8542020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17382-3https://doaj.org/toc/2041-1723Recent studies suggest spatial segregation of tumor initiation and manifestation in IDH-WT glioblastomas. Here, the authors use serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree building to establish this unique evolutionary mode in a murine model.Yinghua LiBo LiWei LiYuan WangSeçkin AkgülDaniel M. TreismanKevin A. HeistBrianna R. PierceBenjamin HoffCheng-Ying HoDavid O. FergusonAlnawaz RehemtullaSiyuan ZhengBrian D. RossJun Z. LiYuan ZhuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yinghua Li Bo Li Wei Li Yuan Wang Seçkin Akgül Daniel M. Treisman Kevin A. Heist Brianna R. Pierce Benjamin Hoff Cheng-Ying Ho David O. Ferguson Alnawaz Rehemtulla Siyuan Zheng Brian D. Ross Jun Z. Li Yuan Zhu Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
description	Recent studies suggest spatial segregation of tumor initiation and manifestation in IDH-WT glioblastomas. Here, the authors use serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree building to establish this unique evolutionary mode in a murine model.
format	article
author	Yinghua Li Bo Li Wei Li Yuan Wang Seçkin Akgül Daniel M. Treisman Kevin A. Heist Brianna R. Pierce Benjamin Hoff Cheng-Ying Ho David O. Ferguson Alnawaz Rehemtulla Siyuan Zheng Brian D. Ross Jun Z. Li Yuan Zhu
author_facet	Yinghua Li Bo Li Wei Li Yuan Wang Seçkin Akgül Daniel M. Treisman Kevin A. Heist Brianna R. Pierce Benjamin Hoff Cheng-Ying Ho David O. Ferguson Alnawaz Rehemtulla Siyuan Zheng Brian D. Ross Jun Z. Li Yuan Zhu
author_sort	Yinghua Li
title	Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
title_short	Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
title_full	Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
title_fullStr	Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
title_full_unstemmed	Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
title_sort	murine models of idh-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4bdb60bfd8b842efb554542d31c8e854
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Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution

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