Oxidation and alkylation stresses activate ribosome-quality control

The mRNA-surveillance pathway of no-go decay (NGD) is a eukaryotic ribosome-based-quality-control process that targets transcripts that stall the ribosome. Here the authors show no-go decay (NGD) and ribosome-quality control (RQC) pathways are activated by mRNAs damaged by alkylation and oxidation s...

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Auteurs principaux:	Liewei L. Yan, Carrie L. Simms, Fionn McLoughlin, Richard D. Vierstra, Hani S. Zaher
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4bdc7027d15d45759a4f1b0de623dfef
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spelling	oai:doaj.org-article:4bdc7027d15d45759a4f1b0de623dfef2021-12-02T17:02:03ZOxidation and alkylation stresses activate ribosome-quality control10.1038/s41467-019-13579-32041-1723https://doaj.org/article/4bdc7027d15d45759a4f1b0de623dfef2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13579-3https://doaj.org/toc/2041-1723The mRNA-surveillance pathway of no-go decay (NGD) is a eukaryotic ribosome-based-quality-control process that targets transcripts that stall the ribosome. Here the authors show no-go decay (NGD) and ribosome-quality control (RQC) pathways are activated by mRNAs damaged by alkylation and oxidation stress.Liewei L. YanCarrie L. SimmsFionn McLoughlinRichard D. VierstraHani S. ZaherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liewei L. Yan Carrie L. Simms Fionn McLoughlin Richard D. Vierstra Hani S. Zaher Oxidation and alkylation stresses activate ribosome-quality control
description	The mRNA-surveillance pathway of no-go decay (NGD) is a eukaryotic ribosome-based-quality-control process that targets transcripts that stall the ribosome. Here the authors show no-go decay (NGD) and ribosome-quality control (RQC) pathways are activated by mRNAs damaged by alkylation and oxidation stress.
format	article
author	Liewei L. Yan Carrie L. Simms Fionn McLoughlin Richard D. Vierstra Hani S. Zaher
author_facet	Liewei L. Yan Carrie L. Simms Fionn McLoughlin Richard D. Vierstra Hani S. Zaher
author_sort	Liewei L. Yan
title	Oxidation and alkylation stresses activate ribosome-quality control
title_short	Oxidation and alkylation stresses activate ribosome-quality control
title_full	Oxidation and alkylation stresses activate ribosome-quality control
title_fullStr	Oxidation and alkylation stresses activate ribosome-quality control
title_full_unstemmed	Oxidation and alkylation stresses activate ribosome-quality control
title_sort	oxidation and alkylation stresses activate ribosome-quality control
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4bdc7027d15d45759a4f1b0de623dfef
work_keys_str_mv	AT lieweilyan oxidationandalkylationstressesactivateribosomequalitycontrol AT carrielsimms oxidationandalkylationstressesactivateribosomequalitycontrol AT fionnmcloughlin oxidationandalkylationstressesactivateribosomequalitycontrol AT richarddvierstra oxidationandalkylationstressesactivateribosomequalitycontrol AT haniszaher oxidationandalkylationstressesactivateribosomequalitycontrol
_version_	1718381966345109504

Oxidation and alkylation stresses activate ribosome-quality control

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