Oxidation and alkylation stresses activate ribosome-quality control

The mRNA-surveillance pathway of no-go decay (NGD) is a eukaryotic ribosome-based-quality-control process that targets transcripts that stall the ribosome. Here the authors show no-go decay (NGD) and ribosome-quality control (RQC) pathways are activated by mRNAs damaged by alkylation and oxidation s...

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Autores principales: Liewei L. Yan, Carrie L. Simms, Fionn McLoughlin, Richard D. Vierstra, Hani S. Zaher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4bdc7027d15d45759a4f1b0de623dfef
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