PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing

There is little known about the function or molecular identity of the electron-dense stereocilia coat, which is transiently present at the surface of stereocilia. In this study authors screened a database of hair-cell-enriched translated proteins to identify the expression of Polycystic Kidney and H...

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Autores principales:	Xudong Wu, Maryna V. Ivanchenko, Hoor Al Jandal, Marcelo Cicconet, Artur A. Indzhykulian, David P. Corey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bdcaffb0a724a74bc4fa26a807e9ed8
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spelling	oai:doaj.org-article:4bdcaffb0a724a74bc4fa26a807e9ed82021-12-02T14:38:59ZPKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing10.1038/s41467-019-11712-w2041-1723https://doaj.org/article/4bdcaffb0a724a74bc4fa26a807e9ed82019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11712-whttps://doaj.org/toc/2041-1723There is little known about the function or molecular identity of the electron-dense stereocilia coat, which is transiently present at the surface of stereocilia. In this study authors screened a database of hair-cell-enriched translated proteins to identify the expression of Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1), a large, mostly extracellular protein, and show that it forms the coat at the tips of stereocilia and is required for normal hearing in miceXudong WuMaryna V. IvanchenkoHoor Al JandalMarcelo CicconetArtur A. IndzhykulianDavid P. CoreyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xudong Wu Maryna V. Ivanchenko Hoor Al Jandal Marcelo Cicconet Artur A. Indzhykulian David P. Corey PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing
description	There is little known about the function or molecular identity of the electron-dense stereocilia coat, which is transiently present at the surface of stereocilia. In this study authors screened a database of hair-cell-enriched translated proteins to identify the expression of Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1), a large, mostly extracellular protein, and show that it forms the coat at the tips of stereocilia and is required for normal hearing in mice
format	article
author	Xudong Wu Maryna V. Ivanchenko Hoor Al Jandal Marcelo Cicconet Artur A. Indzhykulian David P. Corey
author_facet	Xudong Wu Maryna V. Ivanchenko Hoor Al Jandal Marcelo Cicconet Artur A. Indzhykulian David P. Corey
author_sort	Xudong Wu
title	PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing
title_short	PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing
title_full	PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing
title_fullStr	PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing
title_full_unstemmed	PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing
title_sort	pkhd1l1 is a coat protein of hair-cell stereocilia and is required for normal hearing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4bdcaffb0a724a74bc4fa26a807e9ed8
work_keys_str_mv	AT xudongwu pkhd1l1isacoatproteinofhaircellstereociliaandisrequiredfornormalhearing AT marynavivanchenko pkhd1l1isacoatproteinofhaircellstereociliaandisrequiredfornormalhearing AT hooraljandal pkhd1l1isacoatproteinofhaircellstereociliaandisrequiredfornormalhearing AT marcelocicconet pkhd1l1isacoatproteinofhaircellstereociliaandisrequiredfornormalhearing AT arturaindzhykulian pkhd1l1isacoatproteinofhaircellstereociliaandisrequiredfornormalhearing AT davidpcorey pkhd1l1isacoatproteinofhaircellstereociliaandisrequiredfornormalhearing
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PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing

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