Polyethylenimine-based micro/nanoparticles as vaccine adjuvants

Chen Shen,1 Jun Li,1 Yi Zhang,1 Yuce Li,2 Guanxin Shen,3 Jintao Zhu,2 Juan Tao1 1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2School of Chemistry and Chemical Engineering, Huazhong University of Science and Technolo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shen C, Li J, Zhang Y, Li Y, Shen G, Zhu J, Tao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Polyethyleneimine Vaccine Adjuvants Immune Activating Mechanisms Danger Signals Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4bdff68c9b2743a6b5ae2d9358a4bd79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4bdff68c9b2743a6b5ae2d9358a4bd79
record_format	dspace
spelling	oai:doaj.org-article:4bdff68c9b2743a6b5ae2d9358a4bd792021-12-02T02:56:02ZPolyethylenimine-based micro/nanoparticles as vaccine adjuvants1178-2013https://doaj.org/article/4bdff68c9b2743a6b5ae2d9358a4bd792017-07-01T00:00:00Zhttps://www.dovepress.com/polyethylenimine-based-micronanoparticles-as-vaccine-adjuvants-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chen Shen,1 Jun Li,1 Yi Zhang,1 Yuce Li,2 Guanxin Shen,3 Jintao Zhu,2 Juan Tao1 1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China; 3Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Abstract: Vaccines have shown great success in treating and preventing tumors and infections, while adjuvants are always demanded to ensure potent immune responses. Polyethylenimine (PEI), as one of the well-studied cationic polymers, has been used as a transfection reagent for decades. However, increasing evidence has shown that PEI-based particles are also capable of acting as adjuvants. In this paper, we briefly review the physicochemical properties and the broad applications of PEI in different fields, and elaborate on the intracellular processes of PEI-based vaccines. In addition, we sum up the proof of their in vivo and clinical applications. We also highlight some mechanisms proposed for the intrinsic immunoactivation function of PEI, followed by the challenges and future perspectives of the applications of PEI in the vaccines, as well as some strategies to elicit the desirable immune responses. Keywords: cationic polymers, APCs, immunoactivation, danger signals, anti-infection, anticancerShen CLi JZhang YLi YShen GZhu JTao JDove Medical PressarticlePolyethyleneimineVaccine AdjuvantsImmune Activating MechanismsDanger SignalsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5443-5460 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polyethyleneimine Vaccine Adjuvants Immune Activating Mechanisms Danger Signals Medicine (General) R5-920
spellingShingle	Polyethyleneimine Vaccine Adjuvants Immune Activating Mechanisms Danger Signals Medicine (General) R5-920 Shen C Li J Zhang Y Li Y Shen G Zhu J Tao J Polyethylenimine-based micro/nanoparticles as vaccine adjuvants
description	Chen Shen,1 Jun Li,1 Yi Zhang,1 Yuce Li,2 Guanxin Shen,3 Jintao Zhu,2 Juan Tao1 1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China; 3Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Abstract: Vaccines have shown great success in treating and preventing tumors and infections, while adjuvants are always demanded to ensure potent immune responses. Polyethylenimine (PEI), as one of the well-studied cationic polymers, has been used as a transfection reagent for decades. However, increasing evidence has shown that PEI-based particles are also capable of acting as adjuvants. In this paper, we briefly review the physicochemical properties and the broad applications of PEI in different fields, and elaborate on the intracellular processes of PEI-based vaccines. In addition, we sum up the proof of their in vivo and clinical applications. We also highlight some mechanisms proposed for the intrinsic immunoactivation function of PEI, followed by the challenges and future perspectives of the applications of PEI in the vaccines, as well as some strategies to elicit the desirable immune responses. Keywords: cationic polymers, APCs, immunoactivation, danger signals, anti-infection, anticancer
format	article
author	Shen C Li J Zhang Y Li Y Shen G Zhu J Tao J
author_facet	Shen C Li J Zhang Y Li Y Shen G Zhu J Tao J
author_sort	Shen C
title	Polyethylenimine-based micro/nanoparticles as vaccine adjuvants
title_short	Polyethylenimine-based micro/nanoparticles as vaccine adjuvants
title_full	Polyethylenimine-based micro/nanoparticles as vaccine adjuvants
title_fullStr	Polyethylenimine-based micro/nanoparticles as vaccine adjuvants
title_full_unstemmed	Polyethylenimine-based micro/nanoparticles as vaccine adjuvants
title_sort	polyethylenimine-based micro/nanoparticles as vaccine adjuvants
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4bdff68c9b2743a6b5ae2d9358a4bd79
work_keys_str_mv	AT shenc polyethyleniminebasedmicronanoparticlesasvaccineadjuvants AT lij polyethyleniminebasedmicronanoparticlesasvaccineadjuvants AT zhangy polyethyleniminebasedmicronanoparticlesasvaccineadjuvants AT liy polyethyleniminebasedmicronanoparticlesasvaccineadjuvants AT sheng polyethyleniminebasedmicronanoparticlesasvaccineadjuvants AT zhuj polyethyleniminebasedmicronanoparticlesasvaccineadjuvants AT taoj polyethyleniminebasedmicronanoparticlesasvaccineadjuvants
_version_	1718402040038686720

Polyethylenimine-based micro/nanoparticles as vaccine adjuvants

Ejemplares similares