A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and improves motility.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, Seung-Jae V. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4be13eaae3814a74aa5a5c7e9ff9e0a6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4be13eaae3814a74aa5a5c7e9ff9e0a6
record_format	dspace
spelling	oai:doaj.org-article:4be13eaae3814a74aa5a5c7e9ff9e0a62021-12-02T15:15:05ZA PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling10.1038/s41467-021-25920-w2041-1723https://doaj.org/article/4be13eaae3814a74aa5a5c7e9ff9e0a62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25920-whttps://doaj.org/toc/2041-1723Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and improves motility.Hae-Eun H. ParkWooseon HwangSeokjin HamEunah KimOzlem AltintasSangsoon ParkHeehwa G. SonYujin LeeDongyeop LeeWon Do HeoSeung-Jae V. LeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hae-Eun H. Park Wooseon Hwang Seokjin Ham Eunah Kim Ozlem Altintas Sangsoon Park Heehwa G. Son Yujin Lee Dongyeop Lee Won Do Heo Seung-Jae V. Lee A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
description	Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and improves motility.
format	article
author	Hae-Eun H. Park Wooseon Hwang Seokjin Ham Eunah Kim Ozlem Altintas Sangsoon Park Heehwa G. Son Yujin Lee Dongyeop Lee Won Do Heo Seung-Jae V. Lee
author_facet	Hae-Eun H. Park Wooseon Hwang Seokjin Ham Eunah Kim Ozlem Altintas Sangsoon Park Heehwa G. Son Yujin Lee Dongyeop Lee Won Do Heo Seung-Jae V. Lee
author_sort	Hae-Eun H. Park
title	A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
title_short	A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
title_full	A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
title_fullStr	A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
title_full_unstemmed	A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
title_sort	pten variant uncouples longevity from impaired fitness in caenorhabditis elegans with reduced insulin/igf-1 signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4be13eaae3814a74aa5a5c7e9ff9e0a6
work_keys_str_mv	AT haeeunhpark aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT wooseonhwang aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT seokjinham aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT eunahkim aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT ozlemaltintas aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT sangsoonpark aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT heehwagson aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT yujinlee aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT dongyeoplee aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT wondoheo aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT seungjaevlee aptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT haeeunhpark ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT wooseonhwang ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT seokjinham ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT eunahkim ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT ozlemaltintas ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT sangsoonpark ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT heehwagson ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT yujinlee ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT dongyeoplee ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT wondoheo ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling AT seungjaevlee ptenvariantuncoupleslongevityfromimpairedfitnessincaenorhabditiseleganswithreducedinsulinigf1signaling
_version_	1718387566194982912

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Ejemplares similares