Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria

Abstract Most epidemiologic studies assessing the relationship between chronic kidney disease (CKD) and sarcopenia have been performed in dialysis patients. This study aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR), proteinuria, and sarcopenia in patients with...

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Autores principales:	Jung Nam An, Jwa-Kyung Kim, Hyung-Seok Lee, Sung Gyun Kim, Hyung Jik Kim, Young Rim Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4be152a12f6d43ea92bac6b3bc812982
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spelling	oai:doaj.org-article:4be152a12f6d43ea92bac6b3bc8129822021-12-02T18:33:47ZLate stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria10.1038/s41598-021-97952-72045-2322https://doaj.org/article/4be152a12f6d43ea92bac6b3bc8129822021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97952-7https://doaj.org/toc/2045-2322Abstract Most epidemiologic studies assessing the relationship between chronic kidney disease (CKD) and sarcopenia have been performed in dialysis patients. This study aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR), proteinuria, and sarcopenia in patients with non-dialysis-dependent CKD. A total of 892 outpatients who did not show any rapid changes in renal function were enrolled in this observational cohort study. We measured the muscle mass using bioimpedance analysis and handgrip strength (HGS), and sarcopenia was defined as low HGS and low muscle mass. Sarcopenia was found in 28.1% of the patients and its prevalence decreased as the body mass index (BMI) increased; however, in patients with BMI ≥ 23 kg/m2, the prevalence did not increase with BMI. As eGFR decreased, the lean tissue index and HGS significantly decreased. However, the eGFR did not affect the fat tissue index. The risk of sarcopenia increased approximately 1.6 times in patients with eGFR < 45 mL/min/1.73 m2. However, proteinuria was not associated with sarcopenia. With a decrease in eGFR, the lean muscle mass and muscle strength decreased, and the prevalence of sarcopenia increased. In patients with late stage 3 CKD, further assessment of body composition and screening for sarcopenia may be needed.Jung Nam AnJwa-Kyung KimHyung-Seok LeeSung Gyun KimHyung Jik KimYoung Rim SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung Nam An Jwa-Kyung Kim Hyung-Seok Lee Sung Gyun Kim Hyung Jik Kim Young Rim Song Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria
description	Abstract Most epidemiologic studies assessing the relationship between chronic kidney disease (CKD) and sarcopenia have been performed in dialysis patients. This study aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR), proteinuria, and sarcopenia in patients with non-dialysis-dependent CKD. A total of 892 outpatients who did not show any rapid changes in renal function were enrolled in this observational cohort study. We measured the muscle mass using bioimpedance analysis and handgrip strength (HGS), and sarcopenia was defined as low HGS and low muscle mass. Sarcopenia was found in 28.1% of the patients and its prevalence decreased as the body mass index (BMI) increased; however, in patients with BMI ≥ 23 kg/m2, the prevalence did not increase with BMI. As eGFR decreased, the lean tissue index and HGS significantly decreased. However, the eGFR did not affect the fat tissue index. The risk of sarcopenia increased approximately 1.6 times in patients with eGFR < 45 mL/min/1.73 m2. However, proteinuria was not associated with sarcopenia. With a decrease in eGFR, the lean muscle mass and muscle strength decreased, and the prevalence of sarcopenia increased. In patients with late stage 3 CKD, further assessment of body composition and screening for sarcopenia may be needed.
format	article
author	Jung Nam An Jwa-Kyung Kim Hyung-Seok Lee Sung Gyun Kim Hyung Jik Kim Young Rim Song
author_facet	Jung Nam An Jwa-Kyung Kim Hyung-Seok Lee Sung Gyun Kim Hyung Jik Kim Young Rim Song
author_sort	Jung Nam An
title	Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria
title_short	Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria
title_full	Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria
title_fullStr	Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria
title_full_unstemmed	Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria
title_sort	late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4be152a12f6d43ea92bac6b3bc812982
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Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria

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