Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels

Elizabeth Thrift,1 Justin A Wimpole,2 Georgina Child,2 Narelle Brown,1 Barbara Gandolfi,3 Richard Malik4 1Animal Referral Hospital, 2Small Animal Specialist Hospital, Sydney, NSW, Australia; 3Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA;...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thrift E, Wimpole JA, Child G, Brown N, Gandolfi B, Malik R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	malignant hyperthermia canine stress syndrome coagulopathy dog English springer spaniel Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/4be21409e0424734b487dee1a6d59891
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4be21409e0424734b487dee1a6d59891
record_format	dspace
spelling	oai:doaj.org-article:4be21409e0424734b487dee1a6d598912021-12-02T07:10:35ZExercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels2230-2034https://doaj.org/article/4be21409e0424734b487dee1a6d598912017-09-01T00:00:00Zhttps://www.dovepress.com/exercise-induced-hyperthermia-syndrome-canine-stress-syndrome-in-four--peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Elizabeth Thrift,1 Justin A Wimpole,2 Georgina Child,2 Narelle Brown,1 Barbara Gandolfi,3 Richard Malik4 1Animal Referral Hospital, 2Small Animal Specialist Hospital, Sydney, NSW, Australia; 3Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA; 4Centre for Veterinary Education, University of Sydney, Sydney, NSW, Australia Objective: This retrospective study describes the signalment, clinical presentation, diagnostic findings, and mode of inheritance in four young male English springer spaniel dogs with presumptive canine stress syndrome.Materials and methods: Appropriate cases were located through medical searches of medical records of two large private referral centers. Inclusion criteria comprised of English springer spaniel dogs with tachypnea and hyperthermia that subsequently developed weakness or collapse, with or without signs of hemorrhage, soon after a period of mild-to-moderate exercise. The pedigrees of the four affected dogs, as well as eleven related English springer spaniels, were then analyzed to determine a presumptive mode of genetic inheritance.Results: Four dogs met the inclusion criteria. All four were male, suggesting the possibility of a recessive sex-linked heritable disorder. Pedigree analysis suggests that more dogs may be potentially affected, although these dogs may have never had the concurrent triggering drug/activity/event to precipitate the clinical syndrome. There was complete resolution of clinical signs in three of the four dogs with aggressive symptomatic and supportive therapy, with one dog dying during treatment.Conclusion: Dogs with canine stress syndrome have the potential for rapid recovery if treated aggressively and the complications of the disease (eg, coagulopathy) are anticipated. All four dogs were male, suggesting the possibility of a recessive sex-linked mode of inheritance. Further genetic analyses should be strongly considered by those involved with the English springer spaniel breed, either with a genome-wide association study using canine single-nucleotide polymorphism arrays or whole-genome sequencing of affected and closely related dogs. Keywords: malignant hyperthermia, canine stress syndrome, coagulopathy, dog, English springer spanielThrift EWimpole JAChild GBrown NGandolfi BMalik RDove Medical Pressarticlemalignant hyperthermiacanine stress syndromecoagulopathydogEnglish springer spanielVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 8, Pp 59-68 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant hyperthermia canine stress syndrome coagulopathy dog English springer spaniel Veterinary medicine SF600-1100
spellingShingle	malignant hyperthermia canine stress syndrome coagulopathy dog English springer spaniel Veterinary medicine SF600-1100 Thrift E Wimpole JA Child G Brown N Gandolfi B Malik R Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels
description	Elizabeth Thrift,1 Justin A Wimpole,2 Georgina Child,2 Narelle Brown,1 Barbara Gandolfi,3 Richard Malik4 1Animal Referral Hospital, 2Small Animal Specialist Hospital, Sydney, NSW, Australia; 3Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA; 4Centre for Veterinary Education, University of Sydney, Sydney, NSW, Australia Objective: This retrospective study describes the signalment, clinical presentation, diagnostic findings, and mode of inheritance in four young male English springer spaniel dogs with presumptive canine stress syndrome.Materials and methods: Appropriate cases were located through medical searches of medical records of two large private referral centers. Inclusion criteria comprised of English springer spaniel dogs with tachypnea and hyperthermia that subsequently developed weakness or collapse, with or without signs of hemorrhage, soon after a period of mild-to-moderate exercise. The pedigrees of the four affected dogs, as well as eleven related English springer spaniels, were then analyzed to determine a presumptive mode of genetic inheritance.Results: Four dogs met the inclusion criteria. All four were male, suggesting the possibility of a recessive sex-linked heritable disorder. Pedigree analysis suggests that more dogs may be potentially affected, although these dogs may have never had the concurrent triggering drug/activity/event to precipitate the clinical syndrome. There was complete resolution of clinical signs in three of the four dogs with aggressive symptomatic and supportive therapy, with one dog dying during treatment.Conclusion: Dogs with canine stress syndrome have the potential for rapid recovery if treated aggressively and the complications of the disease (eg, coagulopathy) are anticipated. All four dogs were male, suggesting the possibility of a recessive sex-linked mode of inheritance. Further genetic analyses should be strongly considered by those involved with the English springer spaniel breed, either with a genome-wide association study using canine single-nucleotide polymorphism arrays or whole-genome sequencing of affected and closely related dogs. Keywords: malignant hyperthermia, canine stress syndrome, coagulopathy, dog, English springer spaniel
format	article
author	Thrift E Wimpole JA Child G Brown N Gandolfi B Malik R
author_facet	Thrift E Wimpole JA Child G Brown N Gandolfi B Malik R
author_sort	Thrift E
title	Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels
title_short	Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels
title_full	Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels
title_fullStr	Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels
title_full_unstemmed	Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels
title_sort	exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male english springer spaniels
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4be21409e0424734b487dee1a6d59891
work_keys_str_mv	AT thrifte exerciseinducedhyperthermiasyndromecaninestresssyndromeinfourrelatedmaleenglishspringerspaniels AT wimpoleja exerciseinducedhyperthermiasyndromecaninestresssyndromeinfourrelatedmaleenglishspringerspaniels AT childg exerciseinducedhyperthermiasyndromecaninestresssyndromeinfourrelatedmaleenglishspringerspaniels AT brownn exerciseinducedhyperthermiasyndromecaninestresssyndromeinfourrelatedmaleenglishspringerspaniels AT gandolfib exerciseinducedhyperthermiasyndromecaninestresssyndromeinfourrelatedmaleenglishspringerspaniels AT malikr exerciseinducedhyperthermiasyndromecaninestresssyndromeinfourrelatedmaleenglishspringerspaniels
_version_	1718399566961704960

Exercise-induced hyperthermia syndrome (canine stress syndrome) in four related male English springer spaniels

Ejemplares similares