A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex

Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally...

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Autores principales:	Alessio Fragasso, Hendrik W. de Vries, John Andersson, Eli O. van der Sluis, Erik van der Giessen, Andreas Dahlin, Patrick R. Onck, Cees Dekker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4be48fd698744ead86133548fa049b92
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spelling	oai:doaj.org-article:4be48fd698744ead86133548fa049b922021-12-02T13:26:41ZA designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex10.1038/s41467-021-22293-y2041-1723https://doaj.org/article/4be48fd698744ead86133548fa049b922021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22293-yhttps://doaj.org/toc/2041-1723Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally designed artificial FG-Nup that demonstrates that no specific spacer sequence nor a spatial segregation of different FG-motif types are needed to create selective NPCs.Alessio FragassoHendrik W. de VriesJohn AnderssonEli O. van der SluisErik van der GiessenAndreas DahlinPatrick R. OnckCees DekkerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessio Fragasso Hendrik W. de Vries John Andersson Eli O. van der Sluis Erik van der Giessen Andreas Dahlin Patrick R. Onck Cees Dekker A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
description	Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selective behaviour of the NPC by introducing a rationally designed artificial FG-Nup that demonstrates that no specific spacer sequence nor a spatial segregation of different FG-motif types are needed to create selective NPCs.
format	article
author	Alessio Fragasso Hendrik W. de Vries John Andersson Eli O. van der Sluis Erik van der Giessen Andreas Dahlin Patrick R. Onck Cees Dekker
author_facet	Alessio Fragasso Hendrik W. de Vries John Andersson Eli O. van der Sluis Erik van der Giessen Andreas Dahlin Patrick R. Onck Cees Dekker
author_sort	Alessio Fragasso
title	A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
title_short	A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
title_full	A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
title_fullStr	A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
title_full_unstemmed	A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex
title_sort	designer fg-nup that reconstitutes the selective transport barrier of the nuclear pore complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4be48fd698744ead86133548fa049b92
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A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex

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